ID   UFC1_RAT                Reviewed;         167 AA.
AC   Q6BBI8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1 {ECO:0000305};
DE            Short=Ufm1-conjugating enzyme 1 {ECO:0000250|UniProtKB:Q9Y3C8};
GN   Name=Ufc1 {ECO:0000312|RGD:1303313};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tazawa S., Zhang J., Tian Q., Saitoh F., Suzuki T.;
RT   "Postsynaptic distribution of Ufc1 protein.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: E1-like enzyme which specifically catalyzes the second step
CC       in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1
CC       enzyme UBA5 and forms an intermediate with UFM1 via a thioester
CC       linkage. Ufmylation is involved in reticulophagy (also called ER-phagy)
CC       induced in response to endoplasmic reticulum stress.
CC       {ECO:0000250|UniProtKB:Q9Y3C8}.
CC   -!- SUBUNIT: Interacts with UBA5 (via C-terminus). Interacts with UFL1.
CC       Interacts with KIRREL3. Interacts with UFM1.
CC       {ECO:0000250|UniProtKB:Q9Y3C8}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB186051; BAD34943.1; -; mRNA.
DR   EMBL; BC087648; AAH87648.1; -; mRNA.
DR   RefSeq; NP_001003709.1; NM_001003709.2.
DR   RefSeq; XP_006250313.1; XM_006250251.2.
DR   AlphaFoldDB; Q6BBI8; -.
DR   BMRB; Q6BBI8; -.
DR   SMR; Q6BBI8; -.
DR   STRING; 10116.ENSRNOP00000004938; -.
DR   iPTMnet; Q6BBI8; -.
DR   PhosphoSitePlus; Q6BBI8; -.
DR   SwissPalm; Q6BBI8; -.
DR   jPOST; Q6BBI8; -.
DR   PaxDb; Q6BBI8; -.
DR   Ensembl; ENSRNOT00000004938; ENSRNOP00000004938; ENSRNOG00000003706.
DR   GeneID; 445268; -.
DR   KEGG; rno:445268; -.
DR   UCSC; RGD:1303313; rat.
DR   CTD; 51506; -.
DR   RGD; 1303313; Ufc1.
DR   eggNOG; KOG3357; Eukaryota.
DR   GeneTree; ENSGT00390000008196; -.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   InParanoid; Q6BBI8; -.
DR   OMA; IKYVQNN; -.
DR   OrthoDB; 1339876at2759; -.
DR   PhylomeDB; Q6BBI8; -.
DR   TreeFam; TF313587; -.
DR   PRO; PR:Q6BBI8; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003706; Expressed in pancreas and 20 other tissues.
DR   Genevisible; Q6BBI8; RN.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; ISS:UniProtKB.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; ISS:UniProtKB.
DR   GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   GO; GO:0061709; P:reticulophagy; ISS:UniProtKB.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..167
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000082615"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3C8"
SQ   SEQUENCE   167 AA;  19492 MW;  B78DB4F2DC1FEE1F CRC64;
     MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK
     EGTRWFGKCW YIHDFLKYEF DIEFEIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGLAHLMAL GLGPWLAVEV PDLIQKGVIQ HKEKCNQ