ID   UFC1_SALSA              Reviewed;         167 AA.
AC   B9EM04; B9EMN4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1 {ECO:0000305};
DE   AltName: Full=Ufm1-conjugating enzyme 1 {ECO:0000250|UniProtKB:Q9Y3C8};
GN   Name=ufc1 {ECO:0000250|UniProtKB:Q9Y3C8};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Thyroid;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: E1-like enzyme which specifically catalyzes the second step
CC       in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1
CC       enzyme UBA5 and forms an intermediate with UFM1 via a thioester
CC       linkage. Ufmylation is involved in reticulophagy (also called ER-phagy)
CC       induced in response to endoplasmic reticulum stress.
CC       {ECO:0000250|UniProtKB:Q9Y3C8}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BT056679; ACM08551.1; -; mRNA.
DR   EMBL; BT056909; ACM08781.1; -; mRNA.
DR   EMBL; BT057397; ACM09269.1; -; mRNA.
DR   EMBL; BT057543; ACM09415.1; -; mRNA.
DR   RefSeq; NP_001140127.1; NM_001146655.1.
DR   AlphaFoldDB; B9EM04; -.
DR   SMR; B9EM04; -.
DR   STRING; 8030.ENSSSAP00000016166; -.
DR   GeneID; 100286715; -.
DR   KEGG; sasa:100286715; -.
DR   CTD; 51506; -.
DR   OrthoDB; 1339876at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa11.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; ISS:UniProtKB.
DR   GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   GO; GO:0061709; P:reticulophagy; ISS:UniProtKB.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; PTHR12921; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..167
FT                   /note="Ubiquitin-fold modifier-conjugating enzyme 1"
FT                   /id="PRO_0000391958"
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3C8"
FT   CONFLICT        97
FT                   /note="I -> V (in Ref. 1; ACM08781)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   167 AA;  19251 MW;  5DE06BDBDCE3B97D CRC64;
     MADDATRKAV SEIPLLKTNS GPRDKELWVQ RLREEYLALI KYVENNKTAD NDWFRLESNK
     EGTRWFGKCW YIHDLLKYEF DMEFDIPVTY PSTAPEIAIP ELDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLISKGLIT HREQQGS