ID   UFD1_DICDI              Reviewed;         330 AA.
AC   Q55BK0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Ubiquitin fusion degradation protein 1 homolog;
GN   Name=ufd1; ORFNames=DDB_G0271122;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Functions at a post-ubiquitation step in the ubiquitin fusion
CC       degradation (UFD) pathway. {ECO:0000250}.
CC   -!- PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway.
CC   -!- SIMILARITY: Belongs to the UFD1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71893.1; -; Genomic_DNA.
DR   RefSeq; XP_645814.1; XM_640722.1.
DR   AlphaFoldDB; Q55BK0; -.
DR   SMR; Q55BK0; -.
DR   STRING; 44689.DDB0238023; -.
DR   PaxDb; Q55BK0; -.
DR   EnsemblProtists; EAL71893; EAL71893; DDB_G0271122.
DR   GeneID; 8617805; -.
DR   KEGG; ddi:DDB_G0271122; -.
DR   dictyBase; DDB_G0271122; ufd1.
DR   eggNOG; KOG1816; Eukaryota.
DR   HOGENOM; CLU_037790_2_0_1; -.
DR   InParanoid; Q55BK0; -.
DR   OMA; NIEYPMI; -.
DR   PhylomeDB; Q55BK0; -.
DR   Reactome; R-DDI-8951664; Neddylation.
DR   Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR   UniPathway; UPA00144; -.
DR   PRO; PR:Q55BK0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IBA:GO_Central.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:dictyBase.
DR   Gene3D; 2.40.40.50; -; 1.
DR   InterPro; IPR004854; Ufd1-like.
DR   InterPro; IPR042299; Ufd1-like_Nn.
DR   PANTHER; PTHR12555; PTHR12555; 1.
DR   Pfam; PF03152; UFD1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..330
FT                   /note="Ubiquitin fusion degradation protein 1 homolog"
FT                   /id="PRO_0000328335"
FT   REGION          198..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..259
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  36081 MW;  9CB7F900BA047AC2 CRC64;
     MNLDEYVRSL RGEVMGHHHG GPGRYEQKFK AFPISFLPKE KHSLESGGKI LLPPSALNAL
     SRLNIQYPML FEISNPISGK KSHCGVLEFI AEEGICYLPL WMMQNLQLKE GEFIDIKNAT
     LAKGTFVKIQ PRTSNFIDIS NPKAVLENSL RKFATLTKDD EIMIDYNNTK YYLKVVELKP
     ANAISIIEAD VSVDFAPPMD SKEATSPSTS SPGSHVSGPS KGLTFGPAST SAKPIPGGKK
     KKDESDSDSD SDDEPKFKAF AGTGARLDGK VGTPLGTSPK TLNTNNNNNN NNNNNNNNNN
     NNNNNSNNNN TKNEDTKFKS FSGKGHSLKD