ID   UFD1_DROME              Reviewed;         316 AA.
AC   Q9VTF9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Ubiquitin fusion degradation protein 1 homolog;
DE            Short=UB fusion protein 1;
GN   Name=Ufd1-like; Synonyms=UFD1L; ORFNames=CG6233;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11435701; DOI=10.1159/000056916;
RA   Ratti A., Amati F., Bozzali M., Conti E., Sangiuolo F., Berloco M.,
RA   Palumbo G., Botta A., Pizzutti A., Novelli G., Dallapiccola B.;
RT   "Cloning and molecular characterization of three ubiquitin fusion
RT   degradation 1 (Ufd1) ortholog genes from Xenopus laevis, Gallus gallus and
RT   Drosophila melanogaster.";
RL   Cytogenet. Cell Genet. 92:279-282(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Ovary;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Functions at a post-ubiquitation step in the ubiquitin fusion
CC       degradation (UFD) pathway. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from early embryos through to adulthood.
CC       {ECO:0000269|PubMed:11435701}.
CC   -!- SIMILARITY: Belongs to the UFD1 family. {ECO:0000305}.
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DR   EMBL; AF228282; AAK00730.1; -; mRNA.
DR   EMBL; AF228283; AAK00731.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAF50090.1; -; Genomic_DNA.
DR   EMBL; AY060735; AAL28283.1; -; mRNA.
DR   RefSeq; NP_524023.1; NM_079299.4.
DR   AlphaFoldDB; Q9VTF9; -.
DR   SMR; Q9VTF9; -.
DR   BioGRID; 64626; 14.
DR   DIP; DIP-21844N; -.
DR   IntAct; Q9VTF9; 6.
DR   STRING; 7227.FBpp0075952; -.
DR   PaxDb; Q9VTF9; -.
DR   PRIDE; Q9VTF9; -.
DR   DNASU; 39254; -.
DR   EnsemblMetazoa; FBtr0076223; FBpp0075952; FBgn0036136.
DR   GeneID; 39254; -.
DR   KEGG; dme:Dmel_CG6233; -.
DR   CTD; 39254; -.
DR   FlyBase; FBgn0036136; Ufd1-like.
DR   VEuPathDB; VectorBase:FBgn0036136; -.
DR   eggNOG; KOG1816; Eukaryota.
DR   GeneTree; ENSGT00390000002408; -.
DR   HOGENOM; CLU_037790_2_0_1; -.
DR   InParanoid; Q9VTF9; -.
DR   OMA; KDHSETQ; -.
DR   OrthoDB; 1134444at2759; -.
DR   PhylomeDB; Q9VTF9; -.
DR   Reactome; R-DME-110320; Translesion Synthesis by POLH.
DR   Reactome; R-DME-5689880; Ub-specific processing proteases.
DR   Reactome; R-DME-8951664; Neddylation.
DR   Reactome; R-DME-9755511; KEAP1-NFE2L2 pathway.
DR   SignaLink; Q9VTF9; -.
DR   BioGRID-ORCS; 39254; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 39254; -.
DR   PRO; PR:Q9VTF9; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0036136; Expressed in eye disc (Drosophila) and 26 other tissues.
DR   Genevisible; Q9VTF9; DM.
DR   GO; GO:0000502; C:proteasome complex; NAS:FlyBase.
DR   GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IBA:GO_Central.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:FlyBase.
DR   GO; GO:0098586; P:cellular response to virus; IMP:FlyBase.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:FlyBase.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:FlyBase.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IGI:FlyBase.
DR   GO; GO:0006508; P:proteolysis; IMP:FlyBase.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:FlyBase.
DR   Gene3D; 2.40.40.50; -; 1.
DR   InterPro; IPR004854; Ufd1-like.
DR   InterPro; IPR042299; Ufd1-like_Nn.
DR   PANTHER; PTHR12555; PTHR12555; 1.
DR   Pfam; PF03152; UFD1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..316
FT                   /note="Ubiquitin fusion degradation protein 1 homolog"
FT                   /id="PRO_0000194987"
FT   REGION          284..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  34792 MW;  B7C1EA88CCA5CDA3 CRC64;
     MFHFSGFNMM FPEGRNFHAN YKCFSVSMLP GNERTDVEKG GKIIMPPSAL DTLTRLNVEY
     PMLFKLTNVK KSRSSHAGVL EFVADEGKCY LPHWMMENLL LGEGDILNIE SVSLPVATFS
     KFQPHSTDFL DITNPKAVLE NALRNFACLT RGDVIAIKYN KKVYELCVLE TKPGNAVSII
     ECDMNVEFEA PVGYKDHSET QASGSGQQGA AGTVGGEIAG ATNAILEEVV ETFKGSGVRL
     DGKKKKESQL ETPVVKKVLA RGVPDYDFQF GLIRFDRNIR PISDRSQEDD AVAGNADASD
     AESFHGTGFS MKKTRK