ID   UFD1_SCHPO              Reviewed;         342 AA.
AC   O42915; O13409; O60193; Q1MVD5;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 4.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Ubiquitin fusion degradation protein 1;
DE            Short=UB fusion protein 1;
GN   Name=ufd1; ORFNames=SPBC16A3.09c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Montgomery S.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Labib K.P., Montgomery S., Lenhard M., Kearsey S.E.;
RT   "Genetic analysis of an S. pombe homologue of Ufd1.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 89-294.
RC   STRAIN=358;
RA   Pelletier M.F.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions at a post-ubiquitation step in the ubiquitin fusion
CC       degradation (UFD) pathway. It is required for vegetative growth (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFD1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB87522.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ005825; CAA06722.1; -; mRNA.
DR   EMBL; AJ005824; CAA06721.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAB59876.1; -; Genomic_DNA.
DR   EMBL; AF034137; AAB87522.1; ALT_FRAME; mRNA.
DR   PIR; T43554; T43554.
DR   PIR; T43667; T43667.
DR   RefSeq; NP_596780.1; NM_001023801.2.
DR   AlphaFoldDB; O42915; -.
DR   SMR; O42915; -.
DR   BioGRID; 276180; 15.
DR   STRING; 4896.SPBC16A3.09c.1; -.
DR   iPTMnet; O42915; -.
DR   MaxQB; O42915; -.
DR   PaxDb; O42915; -.
DR   PRIDE; O42915; -.
DR   EnsemblFungi; SPBC16A3.09c.1; SPBC16A3.09c.1:pep; SPBC16A3.09c.
DR   GeneID; 2539623; -.
DR   KEGG; spo:SPBC16A3.09c; -.
DR   PomBase; SPBC16A3.09c; ufd1.
DR   VEuPathDB; FungiDB:SPBC16A3.09c; -.
DR   eggNOG; KOG1816; Eukaryota.
DR   HOGENOM; CLU_037790_1_0_1; -.
DR   InParanoid; O42915; -.
DR   OMA; VMLPGPE; -.
DR   PhylomeDB; O42915; -.
DR   Reactome; R-SPO-110320; Translesion Synthesis by POLH.
DR   Reactome; R-SPO-8951664; Neddylation.
DR   Reactome; R-SPO-9755511; KEAP1-NFE2L2 pathway.
DR   PRO; PR:O42915; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000836; C:Hrd1p ubiquitin ligase complex; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:1990112; C:RQC complex; ISO:PomBase.
DR   GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; ISO:PomBase.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0032183; F:SUMO binding; IPI:PomBase.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR   GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; ISO:PomBase.
DR   GO; GO:0032933; P:SREBP signaling pathway; IMP:PomBase.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISO:PomBase.
DR   Gene3D; 2.40.40.50; -; 1.
DR   InterPro; IPR004854; Ufd1-like.
DR   InterPro; IPR042299; Ufd1-like_Nn.
DR   PANTHER; PTHR12555; PTHR12555; 1.
DR   Pfam; PF03152; UFD1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..342
FT                   /note="Ubiquitin fusion degradation protein 1"
FT                   /id="PRO_0000194988"
FT   REGION          303..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   342 AA;  38226 MW;  2026D502B90DA787 CRC64;
     MFGGSFFSSD DDGFSMMSQL RSAFHNNVNQ RFDTRYRCYP VAMIPGEERP NVNYGGKVIL
     PPSALEKLSR LNVSYPMLFD FENEAAEKKT HGGVLEFIAE EGRVYLPYWM MTTLSLEPGD
     LVRVINTDIA QGSYVKLQPQ SVNFLDITDH RAVLENALRN FSTLTKSDIF EILYNDQVYQ
     IKVIDVQPDD SRHVVSVVET DLVVDFDPPI GYEESLQKNK QQNIAGVQGT MVTKIGYDEL
     VRQGDSNLMK GTGTKLNGKE VAEVPKINLL DVEKQECPAP LILPLGTYFF GYPYKAPSIE
     EDSKKDPNLF KFEGAGTSLR ASRKTNGTMG KGSSDDPIDI DA