UFE1_SCHPO
ID UFE1_SCHPO Reviewed; 319 AA.
AC O94531;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Syntaxin ufe1;
GN Name=ufe1; ORFNames=SPCC895.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP INTERACTION WITH SAD1, AND SUBCELLULAR LOCATION.
RX PubMed=14655046; DOI=10.1007/s00438-003-0938-8;
RA Miki F., Kurabayashi A., Tange Y., Okazaki K., Shimanuki M., Niwa O.;
RT "Two-hybrid search for proteins that interact with Sad1 and Kms1, two
RT membrane-bound components of the spindle pole body in fission yeast.";
RL Mol. Genet. Genomics 270:449-461(2004).
CC -!- FUNCTION: Syntaxin required for targeting and fusion of Golgi-derived
CC retrograde transport vesicles with the ER. {ECO:0000250}.
CC -!- SUBUNIT: Component of a SNARE complex consisting of ufe1, use1, sec20
CC and sec22 or ykt6 (By similarity). Interacts with sad1. {ECO:0000250,
CC ECO:0000269|PubMed:14655046}.
CC -!- INTERACTION:
CC O94531; P87245: kms1; NbExp=3; IntAct=EBI-1542297, EBI-1542265;
CC O94531; Q09825: sad1; NbExp=3; IntAct=EBI-1542297, EBI-929731;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type IV membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22840.1; -; Genomic_DNA.
DR PIR; T41642; T41642.
DR RefSeq; NP_588045.1; NM_001023037.2.
DR AlphaFoldDB; O94531; -.
DR SMR; O94531; -.
DR BioGRID; 275464; 6.
DR IntAct; O94531; 2.
DR STRING; 4896.SPCC895.04c.1; -.
DR MaxQB; O94531; -.
DR PaxDb; O94531; -.
DR EnsemblFungi; SPCC895.04c.1; SPCC895.04c.1:pep; SPCC895.04c.
DR GeneID; 2538886; -.
DR KEGG; spo:SPCC895.04c; -.
DR PomBase; SPCC895.04c; ufe1.
DR VEuPathDB; FungiDB:SPCC895.04c; -.
DR eggNOG; KOG3894; Eukaryota.
DR HOGENOM; CLU_038403_0_0_1; -.
DR InParanoid; O94531; -.
DR OMA; RESVLWF; -.
DR Reactome; R-SPO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:O94531; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; ISS:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:PomBase.
PE 1: Evidence at protein level;
KW Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..319
FT /note="Syntaxin ufe1"
FT /id="PRO_0000210282"
FT TOPO_DOM 1..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..315
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..319
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT DOMAIN 228..290
FT /note="t-SNARE coiled-coil homology"
SQ SEQUENCE 319 AA; 36371 MW; 815CA79647037B7D CRC64;
MTSRTNEFFG LTKNGDIDAA NIPLKRISYT DPFLAEGYRI HETIVNLLVF LKKIRGAYLK
DRTFSNVQRL SKPLMECSLE ELSKLELDEV QRDEIEHEVS SAISSCIHQI AKLQEIVKEQ
QSQIPKKSGW LQGLRDPSKL SKKETLVAHH SSVLWYLQSE LSDVSSVLYH LQDLRLKRGQ
EKRNIASDFL TKNPTDENSA VEIPESELQT FFTQQQLQEL EQENDVLLQE FEHTMERLRD
TGKSLADITR LQSEISAQLS IQSSAAEKLY DDALNVMDSL SGGNQQLIKA KSRSSRTARL
LFCIFTVMGL LLLSLDRIV
