ID   UFL1_AEDAE              Reviewed;         777 AA.
AC   Q0IG18;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   ORFNames=AAEL003536;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
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DR   EMBL; CH477274; EAT45195.1; -; Genomic_DNA.
DR   RefSeq; XP_001656941.1; XM_001656891.1.
DR   AlphaFoldDB; Q0IG18; -.
DR   STRING; 7159.AAEL003536-PA; -.
DR   GeneID; 5578370; -.
DR   KEGG; aag:5578370; -.
DR   VEuPathDB; VectorBase:AAEL003536; -.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; Q0IG18; -.
DR   OMA; NECSATK; -.
DR   OrthoDB; 289380at2759; -.
DR   PhylomeDB; Q0IG18; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..777
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391876"
FT   REGION          396..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..425
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   777 AA;  86040 MW;  E61F1668C4DEFF83 CRC64;
     MTSDWDEIKR LAADFQKAQL STSLQRLSER NCVEVVSLLI EKGLLEVIFT TDGKEYLTQA
     HLAQEVKDEL FVQGGRVNLV DLAKTLNVDF DRVQRVAEQV VQEDPSVKFV LGQLLDVSYF
     ERVAMEVNEK LAQAGEINVA DLTMQYDLPA DFILSNIVLK YLNKIIMGKQ DASNANIFFT
     QSYVTRSKAK IRGALAAITK PTPVSAILAQ CGIPDRLFNM LVNEVATLGS VTSRSPGAQY
     IPHIYRKTQV DWVQNFYRQN GYLEHDSVAG LGVTDVKNFI TNQLPEAKII HLKKCSVGEK
     LIDQVVASLE ECLSSNTYLD VSTILPSIMT DEDIDQLLSM VLTAAMQKQT LIFGSTILTT
     KFVDDIIKPC YGIAEEHAKR SVDSGSYQQY MAEKLMKHQD PMDRDSAVGE GKADKREERR
     KKAAGGKGGG GTQGRETKTK STKKHVRGQK GNVSDSDDDM PSGGKKGGKD AVIELITTKE
     IAKVLEAGLE PEGLEDLSKQ LAQHYYPQFS KLALAKAHQL YEISLHQSNQ NRRQTHASLQ
     DKLNNLYNDI RLYEKGIKLF PADVQPQLVK YLLKSLGTDF SNEICFYVAA ECNLNSNGTT
     LTVEQRNKIV QECSQEYKSA LQALNKAVFS SASIDDFLDV AESALQACSM ILKKIDKKKD
     RNLILCHKHG LLEQLANCSD PALVLHLAVL IIFTICTQSM LHASGRHVSS ILSFLQPQLS
     PEQAQTLTSY HDLVLKLLSA EGSSSNVDDI TKQLEDLTPT VKSIASSFKK SGVTSAE