ID   UFL1_ANOGA              Reviewed;         784 AA.
AC   Q7Q373;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   ORFNames=AGAP007742;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
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DR   EMBL; AAAB01008964; EAA12385.3; -; Genomic_DNA.
DR   RefSeq; XP_317778.3; XM_317778.3.
DR   AlphaFoldDB; Q7Q373; -.
DR   STRING; 7165.AGAP007742-PA; -.
DR   PaxDb; Q7Q373; -.
DR   GeneID; 1278223; -.
DR   KEGG; aga:AgaP_AGAP007742; -.
DR   CTD; 1278223; -.
DR   VEuPathDB; VectorBase:AGAP007742; -.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; Q7Q373; -.
DR   OMA; NECSATK; -.
DR   OrthoDB; 289380at2759; -.
DR   PhylomeDB; Q7Q373; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..784
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391877"
FT   REGION          398..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..422
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   784 AA;  88089 MW;  6E77742247158FDE CRC64;
     MADWDEIKRL AADFQKAQLS TGLQRLSERN CIEIVRLLIE KGLIDVIYTN DGKEYLTQDH
     LKQEVKDELY VRGGRVNLIE LARVLNVDFG KIEYTAKRLV EKDPNLHLLL GQLIETSYLQ
     RLASEINQKL VQYGEIHIGQ LTTTYDLPTD FILNKIVLAN LHKVIFAKQD PTNAHIFFTQ
     SYIARNKAKI RGALAAITKP TPISVILNLT DVPARILYMS LNEMSSLGSV TVQSPAGQYI
     PHVYQRMQAQ WVKDYFKQNG HIMYETVTKL GVSDVRSFVQ AQLPDEKLVQ LKNCIIGNRL
     IDQVKDSMDM CVTSNSYLDI STILPSSLSD DNIEEILTHI LTPTIRKQTY VFGMVVLTVN
     FMDECVKGCL ELVNEHAKRA VESGSYQKYI AEKSIKHQEV DHGVMEEEKA DKREERRKKA
     STGKGGGGAQ GRETKTKSTK KHARGTRGNV SDSDDGGEIQ TNASNKKGGK DPHIELITAK
     EIAKVVEKTL EPEGLEMLAK DVANHYFPIL SKQALVKAHE LYEQSLQKNN QNRRQTHASI
     QEKLNTLYND IRLYEKGLKL FPADVQGQLL KYLLKTFGTD ACNELCLYVA SECNLNTNFN
     APLTTEQRTK IANDSGPEYR PHLQTLCKAL SASETVEDFL DKTEKTMQAC SMMLKKIDKK
     KDRNLILCHK HGLLEQLTNC TDPALVLHLA VLIIFTISTQ TMLHASGRHV SAILTFLQTV
     LSTDDSKVFN NYHDLVLKLL STESSTTEEA KANAEDITKQ LGELTPVVKN IAGNFKKAGV
     TPVE