ID   UFL1_CAEBR              Reviewed;         747 AA.
AC   A8WN14;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2013, sequence version 4.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.- {ECO:0000250|UniProtKB:O94874};
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   Name=ufl-1; ORFNames=CBG00415;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250|UniProtKB:O94874}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE600968; CAP21869.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WN14; -.
DR   STRING; 6238.CBG00415; -.
DR   PRIDE; A8WN14; -.
DR   WormBase; CBG00415; CBP37980; WBGene00023806; Cbr-ufl-1.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_422267_0_0_1; -.
DR   InParanoid; A8WN14; -.
DR   OMA; NMIAGEI; -.
DR   OrthoDB; 289380at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..747
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391892"
FT   REGION          403..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..432
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  81728 MW;  D173489A90FF9E37 CRC64;
     MTSWADIQKL ASDLQRVQLT QSSKKLSEVN CIEVLQKLIA SQQIDVVYTR DGHTYVTKKH
     LETEIKNECV AAGGRAPLTD IAVALNIDFD HIERTARLIV SSDDEFTLSN AELFATGYSL
     CRTKISISVN TCIASATNFA LFSMNKSLLI EKLSSTDFEG VVDGDTIYTS SFLDARQLVL
     RAVLVALTKV TPISTIQKRV GLTPKRFWIA FENLQALGEV PGTLIGSRTS PACSYRPKMY
     DYLVKTCVTN QYRQNEFLQM STLKTLGLDS KTALEEVLGA SEVKKLVNLN SIYMSKELME
     QCVQTVQGEA RNITLNTDYI VFVPDDIQNS GIAEIRMSLQ TLNLPLDTAD EDLIGEKIAS
     TEKDTNFSDG FVYNNSILTE ALKSINTQIE AKAHQEVEKI DVEKKKQCGS KAPAKVQEDT
     DDWGDNKKGG KGGKKGGKGG KNGGGGGKGA TSSVPTGSGT VQVNSEELEE WLRESQTVPE
     EILTVVVETL HQDATSALRK QVQEIQALQL VVNAANSKKS LSAIGDKCRQ LYDSFNTFEA
     GTTSFADPLG TDLRQYLLKT VGVDLACAIL SYAIGIDNVH QLKEKQRDET IESLPEMVRE
     PIRALFASLK STDEDAVEKF HDAVYDCSVP SATSLSLRKI DKKGRAEVGV KVSADLCDQL
     ASQSDPATTL LLSVLYLFSQ AGRPTTASGK FVAQLIAQMK DFCPTNTFEL LQSCQKGVVT
     CIKNQDDDVA KEILSEDIEK LKSAVLQ