ID   UFL1_CAEEL              Reviewed;         735 AA.
AC   Q17750;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.- {ECO:0000250|UniProtKB:O94874};
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   Name=ufl-1; ORFNames=C06G3.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250|UniProtKB:O94874}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
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DR   EMBL; FO080396; CCD83557.1; -; Genomic_DNA.
DR   PIR; T30096; T30096.
DR   RefSeq; NP_501090.1; NM_068689.5.
DR   AlphaFoldDB; Q17750; -.
DR   BioGRID; 42590; 8.
DR   STRING; 6239.C06G3.9.1; -.
DR   EPD; Q17750; -.
DR   PaxDb; Q17750; -.
DR   PeptideAtlas; Q17750; -.
DR   EnsemblMetazoa; C06G3.9.1; C06G3.9.1; WBGene00015555.
DR   GeneID; 177471; -.
DR   KEGG; cel:CELE_C06G3.9; -.
DR   UCSC; C06G3.9.1; c. elegans.
DR   CTD; 177471; -.
DR   WormBase; C06G3.9; CE07985; WBGene00015555; ufl-1.
DR   eggNOG; KOG2235; Eukaryota.
DR   GeneTree; ENSGT00390000002112; -.
DR   HOGENOM; CLU_422267_0_0_1; -.
DR   InParanoid; Q17750; -.
DR   OMA; NMIAGEI; -.
DR   OrthoDB; 289380at2759; -.
DR   PhylomeDB; Q17750; -.
DR   Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q17750; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00015555; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..735
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391893"
FT   REGION          389..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..422
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..445
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  81001 MW;  B3463D49DC293639 CRC64;
     MTSWADIQKL ASDLQRVQLS QSSKKLSEVN CIEVLQKLIA SHRIDVVYTR DGHSYVTKNH
     LETEIKNECI AAGGRASLTD IAVALNIDFD HIEKTSRLIV STDDEFTISN AEIFATEYVH
     RLRNELRTLL DEQGNQTTAA LCKHWNLSSE LLQSLLIEKL GSSDFQGVVD GDTIYTSSFL
     NARQLVLRAI LIALTKITPI STIQKRVGLT PKRFWIAFEN LQSLGEIPGT LIGSRTSPSC
     SYRPMMYDHL VKSCVLNQYR QNEFLEISTL KTLGVDAKPA LEEVLGSSEF KKLVSMRSMF
     MTKELMDQCI NAVQEDLQKS GISDVHLALQ SLNLPLDTAD EDEIGSKVAN VEKDSHFAEG
     FVFKGAVLTE ALRSIDKLLD VRAHEEVDRL EAEKKKQGGA KAAVKVQEET DDWGDGKKGG
     KGGKKNAKSV KGGSKSSAPS TSSNLSANIS INSEELEIWL RESQSVPEEI LSVIVEKLNQ
     ETTTLLRKKV QDIQAHQLVA SVANSKKSLS AIGDKCRQLY DSFNTFETAT STFADPLGSD
     LRQYLLKTVG NEIALALLSY VMGVDNAHQL KEKQREETIE NLPEMLRDPI RSVFASLKST
     DDDALDKFHD AVYNCSAPSA TSLALKKVDK KGRAEVGAKI TAELHEQLCS QTEPATTLLL
     SVLYILAKAG RPTTASGKFV SQLVAQIKDL CPENVFDLLQ ACQKGVVTCI KNKGDEVAKE
     MLVNDISSLK QSIMP