ID   UFL1_CULQU              Reviewed;         785 AA.
AC   B0WU24;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   ORFNames=CPIJ010920;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS232099; EDS34740.1; -; Genomic_DNA.
DR   RefSeq; XP_001857545.1; XM_001857502.1.
DR   AlphaFoldDB; B0WU24; -.
DR   STRING; 7176.CPIJ010920-PA; -.
DR   GeneID; 6043205; -.
DR   KEGG; cqu:CpipJ_CPIJ010920; -.
DR   VEuPathDB; VectorBase:CPIJ010920; -.
DR   VEuPathDB; VectorBase:CQUJHB001851; -.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; B0WU24; -.
DR   OMA; NECSATK; -.
DR   OrthoDB; 289380at2759; -.
DR   PhylomeDB; B0WU24; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..785
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391878"
FT   REGION          396..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..471
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  87098 MW;  EA223805FF85F915 CRC64;
     MTSDWDEIKR LASDFQKAQL TTSLQRLSER NCVEVVSLLI EKGLLEVIYT TDGKEYLTQV
     HLKQEVRDEM FVRGGRVNLV DLSKALTVDF EKVQVVAEQI VVEDRSVKFI LGQLIEQFYM
     ERVASEINEK LAQVGEINVA DLTVQYDLPA DFILNNIILR HLNKTIMGKQ DSSNANIFFT
     QSYVARSKAK VRGALAAITK PTPVSAILAQ CGIPDRLFNL LVNEVATLGS VTSRTPGALY
     IPHIYTKTQV EWVQNFYRQN GYLEHDSVAG LGVTDVKNFI VNQLPNEKIV HLKKCSVGEK
     LIEQVASSLE ECISTSTYLD VSTVLPSIMS DEDVDQLLTI VLTAPMQKQV LIFNSTILTT
     KFVEDMIKPC YDIAVENAKK SVDSGTYQQY MAEKMMKHQD VIPDKESAEN KADKRDERRK
     KAAGGKAGGG AQGRETKTKS TKKHARGHRG NVSDSDEDFG PAEKSAGGKK GAKEASIELI
     TVKDISKVLH GGLEEEGLED LAKQLAQHYY PQFSRLALAK AHELYEISLH QNNQNRRQTH
     ANLQDKLNNL FNDIRLYEKG IKLLPADVQP QLVKYLLKSL GTDFCNEIFF YVAAECNLNS
     NGTTLTVEQR NKIAADCGQE YRGALQALNK ATASSAAVDD FLVVAENSLQ ACSMILKKID
     KKKDRNLILC HKHGLLEQLA NCSDPALVLH LAVLILFTIS TQSMLHASGR HVSAILSFLQ
     PALAPEQAQT LTTYHDLVLK LLSVENASDD SKADADEVKQ QLEKLTPTVK DIAGNYKKAG
     LTSAE