ID   UFL1_DICDI              Reviewed;         799 AA.
AC   Q54QS0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
GN   ORFNames=DDB_G0283667;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000056; EAL65600.1; -; Genomic_DNA.
DR   RefSeq; XP_638953.1; XM_633861.1.
DR   AlphaFoldDB; Q54QS0; -.
DR   STRING; 44689.DDB0234049; -.
DR   PaxDb; Q54QS0; -.
DR   EnsemblProtists; EAL65600; EAL65600; DDB_G0283667.
DR   GeneID; 8624193; -.
DR   KEGG; ddi:DDB_G0283667; -.
DR   dictyBase; DDB_G0283667; -.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; Q54QS0; -.
DR   OMA; NECSATK; -.
DR   PhylomeDB; Q54QS0; -.
DR   Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q54QS0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..799
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000328125"
FT   REGION          429..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..460
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   799 AA;  93288 MW;  8CD2DE0B610E05F3 CRC64;
     MEELEILRKK LYSIQRQDNT QKLSERNCIE IIVKMIDLKM IDIIHSLDGK EYITPKQLEN
     EIKDEILKCG GRVVVCDLQS ILSIDIIHIE EALEKLKKRD KSIQIYQGEI MTRYYLDSIL
     QEIQEQLQEV GKLHINDLSN RFSIGVDFLI NLIEQNLKKF NRSLNNSTNN NNNNNNILLK
     NIIFDNQEVL YTQSHINRHY HKVIGLFSSI TQPILINNVI KQHQNHYQLN ERLVRQQLQE
     LIENKRINGF IQGKASNAEF IPTIFSQSRL KWIDSFYHQN QFITFDSVSK LQINEPQSFL
     KNTFTDGLLL HSCFIHKSLI DKIDDNIIEI IENSNWLDLI PLLPPLTDKD ISMIVSNCPN
     MKTNNAILLG NSFIISKSFV DRCFTLLQKT IQERMEKQQL ILENIASSNI KKQQQSKSEI
     IDQKIETTTT TTTTTQPSKK KDNLINSDDD DNQDNNKKSS KGKNKKSKQQ QSSIQKLIND
     SEDDYKVYNK KQENNNNNKK VDHLKEINQL LSKWYENMEE ELVESLSQYL RPLVNQSWES
     MVKEAKEKLE NETQKQRKQQ LQQLNSQFFS LYNSFLLFRK GLQSLNDADD DNGKTIIALE
     KHLLKTVGIN ITNLLIEINA NYHMLDKTTF ETPSERSLIL SQFPPQLSKS FEKLIQSLNK
     STLNDFIDSL ENVCSQSQIK LKSLDKKLEK QLLIENQNEL EEQFLNEIDV GNQFQIIVNL
     MYIRYKNNYI FSPPRLIGKL VSTLVMDTSI DKEIITRLTK LHQEIVKLIT NNKLSNQDND
     NDSTELNDHI KFFKDLILN