ID   UFL1_DROPS              Reviewed;         785 AA.
AC   Q296V2;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   ORFNames=GA10722;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000070; EAL28355.1; -; Genomic_DNA.
DR   RefSeq; XP_001359210.1; XM_001359173.4.
DR   AlphaFoldDB; Q296V2; -.
DR   STRING; 7237.FBpp0284288; -.
DR   EnsemblMetazoa; FBtr0285850; FBpp0284288; FBgn0070778.
DR   GeneID; 4802251; -.
DR   KEGG; dpo:Dpse_GA10722; -.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; Q296V2; -.
DR   OMA; NECSATK; -.
DR   PhylomeDB; Q296V2; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0070778; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..785
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391885"
FT   REGION          405..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..428
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..468
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  87553 MW;  796AD4AF3621A7AD CRC64;
     MGSDWDEIKR LAADFQKAQL TSTLQKLSER NCVEIVTLLL EKQLLEVVFT NNGKEYITPD
     HLEREIQDEL YANGGRANLV EVSRTLNVDL SRIVALAERI AAENPLVHLV LGQLIDEDYI
     SHIAQEINEK LALRGEISIS DLASQFDLPS EFLQQDVVEK HLGKIIKGRQ DATNPRVFFT
     QAYIQRCKAK IRGALAAITR PTNVAVILQQ INVQEKIFHS LLDEISPAGQ VTSKLANAQY
     VPHIYAKTQA DWVNSFYKQN SFLEYDAINK LGISDAKSYI RKQFPNEEFL FLKRVALGAR
     LVELTVVTAL NECSATKQYL DLTTILPSNL SEEDIEEVFS AIMAQKHSNP SNFVYLDSIV
     FSQPYLTELV QPCHALAEAQ AKAAIDSGVY QQFVVEKTLA QKGNASFQDQ DDDGKLDKRD
     ERRKKASSGK AGGGAQGRET KTKSTKKHQR RSAAAQNDSD DEDDVQHQGS RGAGGGGGNK
     KTVKPLDLVK TADIEKLINA SLQEEGLEHL APSIAALYLN QLNQAALAKA QELYEATPQT
     NRRQTHAAIQ DRINTLLIDI RLYEKGLKLF SHDTQTQLVK YLLKSLGNDI CNELSLYVAS
     ECNLTVKNTS LNVDQRIKLA QECDAEYRSA LLEQNKALNK SIDDFELATE SVLKACSMII
     KKVDKKKDRL LIADHKNKLQ QQLLDCQEPA LLLHLAALIL FTTISGCILH ASGKFVSAIL
     QHIRGSLSDQ QNDMLLRYHD LVLQVLQTAP ESDDSKIAHE QLQIMQSKVV ELAQNYTRAS
     VSKAD