ID   UFL1_NEMVE              Reviewed;         790 AA.
AC   A7S2N8;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=E3 UFM1-protein ligase 1 homolog;
DE            EC=2.3.2.-;
DE   AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000305};
GN   ORFNames=v1g184952;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC       proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UFL1 family. {ECO:0000305}.
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DR   EMBL; DS469569; EDO42037.1; -; Genomic_DNA.
DR   RefSeq; XP_001634100.1; XM_001634050.1.
DR   AlphaFoldDB; A7S2N8; -.
DR   STRING; 45351.EDO42037; -.
DR   EnsemblMetazoa; EDO42037; EDO42037; NEMVEDRAFT_v1g184952.
DR   eggNOG; KOG2235; Eukaryota.
DR   HOGENOM; CLU_012417_1_1_1; -.
DR   InParanoid; A7S2N8; -.
DR   OMA; NECSATK; -.
DR   OrthoDB; 289380at2759; -.
DR   PhylomeDB; A7S2N8; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:0071568; F:UFM1 transferase activity; IBA:GO_Central.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IBA:GO_Central.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR018611; Ufl1.
DR   PANTHER; PTHR31057; PTHR31057; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Ubl conjugation pathway.
FT   CHAIN           1..790
FT                   /note="E3 UFM1-protein ligase 1 homolog"
FT                   /id="PRO_0000391891"
FT   REGION          404..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..469
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   790 AA;  89293 MW;  F4BBE169233A0635 CRC64;
     MADWDEIKKL AADFHRVQLT STAHKLSERN CIEIVQKLIN TGLLEVIYTT DGKEYLTPQQ
     LEREIKDELF VHGGRFFLLN LVDLQQIINV DLSHVDNKVS EILRHDKSLV LIQGDLIDKD
     YLDRMAEEIN ETLQEAGQVF IAELSKTFSL PTDFMLEVVE SRLDIQIMGK LDQMDRNVLY
     THAFIARQTA RMRGVLSAIT RPTQFSNIIS KYGFQEKLFY SVIGDLLSSK RIMGSTQGRQ
     DKISFVPDVY TQAQNNWVDD FFKQNGYVEY DALTRLGITD GKQFLKRRYH GNEIFLPTCC
     VGERVLDQAD AAIDDALSSG TWVDIMPHLP TPFTPDDAEQ LLQHCLKTPG RSTAHVYCSS
     IVASDKFVEA CKAPFETRMH AKAKKDAAES PALFAELSKK DLASLKGGGG GADRREARKE
     DRRKTASSGG KGGGSVGGRG GRETKTKKVK KKDFRNRNDE DDTNEADSRS NPDELQFMTT
     EEIAEVLRKD RPDIDDDFLE ELAQEMHRPL TRAYQQVARA VLQSSGDKKR KSHAEIQEKV
     NALWANAKLF DKSINLFPED VQVHLSRHLL RTVCTDITNL MVNMLAADHM LAVTDETTIT
     PETRLKIIKK MPEEIKAPLT KLNSSLTAKE TEEFFAQFDL VAGQGLCELM IKKLDKKKER
     QISIERRAAL QEQLRHEDEP AMTLHLAVSL LFQHFTSSLL HAPGRCVPQI VALLAEHVTP
     EQHEILLRCQ SLVVKQLTRS GSDEVEEEAG DEHENEAGVE KSTAVLLEEG MREIKKMVLE
     LKKDNSKNES