UFM1_MACFA
ID UFM1_MACFA Reviewed; 85 AA.
AC Q4R4I2;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Ubiquitin-fold modifier 1 {ECO:0000250|UniProtKB:P61960};
DE Flags: Precursor;
GN Name=UFM1 {ECO:0000250|UniProtKB:P61960};
GN ORFNames=QtrA-13634 {ECO:0000303|Ref.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Temporal cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ubiquitin-like modifier which can be covalently attached via
CC an isopeptide bond to lysine residues of substrate proteins as a
CC monomer or a lysine-linked polymer. The so-called ufmylation, requires
CC the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme
CC UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in
CC reticulophagy (also called ER-phagy) induced in response to endoplasmic
CC reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-
CC mediated transcription. {ECO:0000250|UniProtKB:P61960}.
CC -!- SUBUNIT: Interacts with UBA5. Interacts with UFC1.
CC {ECO:0000250|UniProtKB:P61960}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61960}. Cytoplasm
CC {ECO:0000250|UniProtKB:P61960}.
CC -!- SIMILARITY: Belongs to the UFM1 family. {ECO:0000305}.
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DR EMBL; AB169912; BAE01993.1; -; mRNA.
DR RefSeq; XP_005585753.1; XM_005585696.2.
DR AlphaFoldDB; Q4R4I2; -.
DR SMR; Q4R4I2; -.
DR STRING; 9541.XP_005585753.1; -.
DR GeneID; 102146980; -.
DR KEGG; mcf:102146980; -.
DR CTD; 51569; -.
DR VEuPathDB; HostDB:ENSMFAG00000004000; -.
DR eggNOG; KOG3483; Eukaryota.
DR OMA; INPAQNA; -.
DR OrthoDB; 1575050at2759; -.
DR Proteomes; UP000233100; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:1990592; P:protein K69-linked ufmylation; ISS:UniProtKB.
DR GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR GO; GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR GO; GO:0061709; P:reticulophagy; ISS:UniProtKB.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR005375; UFM1.
DR PANTHER; PTHR15825; PTHR15825; 1.
DR Pfam; PF03671; Ufm1; 1.
DR PIRSF; PIRSF038027; Ubiquitin-like_Ufm1; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation;
KW Ubl conjugation pathway.
FT CHAIN 1..83
FT /note="Ubiquitin-fold modifier 1"
FT /id="PRO_0000042124"
FT PROPEP 84..85
FT /note="Removed in mature form"
FT /evidence="ECO:0000250|UniProtKB:P61960"
FT /id="PRO_0000042125"
FT CROSSLNK 69
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in UFM1)"
FT /evidence="ECO:0000250|UniProtKB:P61960"
FT CROSSLNK 83
FT /note="Glycyl lysine isopeptide (Gly-Lys) (interchain with
FT K-? in acceptor proteins)"
FT /evidence="ECO:0000250|UniProtKB:P61960"
SQ SEQUENCE 85 AA; 9118 MW; EDB2412E5E5836D8 CRC64;
MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA
QTAGNVFLKH GSELRIIPRD RVGSC
