ID   UFOG1_MANES             Reviewed;         449 AA.
AC   Q40284;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Anthocyanidin 3-O-glucosyltransferase 1;
DE            EC=2.4.1.115;
DE   AltName: Full=Flavonol 3-O-glucosyltransferase 1;
DE   AltName: Full=UDP-glucose flavonoid 3-O-glucosyltransferase 1;
GN   Name=GT1; Synonyms=UGT73A1;
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cotyledon;
RX   PubMed=7894058; DOI=10.3109/10425179409039703;
RA   Hughes J., Hughes M.A.;
RT   "Multiple secondary plant product UDP-glucose glucosyltransferase genes
RT   expressed in cassava (Manihot esculenta Crantz) cotyledons.";
RL   DNA Seq. 5:41-49(1994).
CC   -!- FUNCTION: In the presence of other necessary color factors, this
CC       glycosylation reaction allows the accumulation of anthocyanin pigments.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an anthocyanidin + H(+) + UDP-alpha-D-glucose = an
CC         anthocyanidin 3-O-beta-D-glucoside + UDP; Xref=Rhea:RHEA:20093,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16307, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:143576; EC=2.4.1.115;
CC   -!- PATHWAY: Pigment biosynthesis; anthocyanin biosynthesis.
CC   -!- TISSUE SPECIFICITY: Expressed in cotyledons and roots, but not in
CC       leaves.
CC   -!- DEVELOPMENTAL STAGE: Maximum expression in cotyledons that just emerged
CC       from the seed coat. Low levels in hypocotyls and increasing levels in
CC       roots throughout this period of development.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X77459; CAA54609.1; -; mRNA.
DR   PIR; S41950; S41950.
DR   AlphaFoldDB; Q40284; -.
DR   SMR; Q40284; -.
DR   STRING; 3983.cassava4.1_031478m; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   UniPathway; UPA00009; -.
DR   GO; GO:0047213; F:anthocyanidin 3-O-glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..449
FT                   /note="Anthocyanidin 3-O-glucosyltransferase 1"
FT                   /id="PRO_0000074143"
SQ   SEQUENCE   449 AA;  50282 MW;  A6738182F316DE75 CRC64;
     MGHLVSAVET AKLLLSRCHS LSITVLIFNN SVVTSKVHNY VDSQIASSSN RLRFIYLPRD
     ETGISSFSSL IEKQKPHVKE SVMKITEFGS SVESPRLVGF IVDMFCTAMI DVANEFGVPS
     YIFYTSGAAF LNFMLHVQKI HDEENFNPTE FNASDGELQV PGLVNSFPSK AMPTAILSKQ
     WFPPLLENTR RYGEAKGVII NTFFELESHA IESFKDPPIY PVGPILDVRS NGRNTNQEIM
     QWLDDQPPSS VVFLCFGSNG SFSKDQVKEI ACALEDSGHR FLWSLADHRA PGFLESPSDY
     EDLQEVLPEG FLERTSGIEK VIGWAPQVAV LAHPATGGLV SHSGWNSILE SIWFGVPVAT
     WPMYAEQQFN AFQMVIELGL AVEIKMDYRN DSGEIVKCDQ IERGIRCLMK HDSDRRKKVK
     EMSEKSRGAL MEGGSSYCWL DNLIKDMIK