ID   UFOG2_MANES             Reviewed;         346 AA.
AC   Q40285;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Anthocyanidin 3-O-glucosyltransferase 2;
DE            EC=2.4.1.115;
DE   AltName: Full=Flavonol 3-O-glucosyltransferase 2;
DE   AltName: Full=UDP-glucose flavonoid 3-O-glucosyltransferase 2;
DE   Flags: Fragment;
GN   Name=GT2; Synonyms=UGT73A2;
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cotyledon;
RX   PubMed=7894058; DOI=10.3109/10425179409039703;
RA   Hughes J., Hughes M.A.;
RT   "Multiple secondary plant product UDP-glucose glucosyltransferase genes
RT   expressed in cassava (Manihot esculenta Crantz) cotyledons.";
RL   DNA Seq. 5:41-49(1994).
CC   -!- FUNCTION: In the presence of other necessary color factors, this
CC       glycosylation reaction allows the accumulation of anthocyanin pigments.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an anthocyanidin + H(+) + UDP-alpha-D-glucose = an
CC         anthocyanidin 3-O-beta-D-glucoside + UDP; Xref=Rhea:RHEA:20093,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16307, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:143576; EC=2.4.1.115;
CC   -!- PATHWAY: Pigment biosynthesis; anthocyanin biosynthesis.
CC   -!- TISSUE SPECIFICITY: Expressed in cotyledons, roots and leaves.
CC   -!- DEVELOPMENTAL STAGE: Maximum expression in cotyledons that just emerged
CC       from the seed coat. Low levels in hypocotyls and increasing levels in
CC       roots throughout this period of development.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X77461; CAA54611.1; -; mRNA.
DR   PIR; S41954; S41954.
DR   AlphaFoldDB; Q40285; -.
DR   SMR; Q40285; -.
DR   STRING; 3983.cassava4.1_018585m; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PRIDE; Q40285; -.
DR   UniPathway; UPA00009; -.
DR   GO; GO:0047213; F:anthocyanidin 3-O-glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           <1..346
FT                   /note="Anthocyanidin 3-O-glucosyltransferase 2"
FT                   /id="PRO_0000074144"
FT   NON_TER         1
SQ   SEQUENCE   346 AA;  38835 MW;  89D51FDFF8E0D5F2 CRC64;
     FCTPMMDLAD EFGIPSYIFF ASGGGFLGFM LYVQKIHDEE NFNPIEFKDS DTELIVPSLV
     NPFPTRILPS SILNKERFGQ LLAIAKKFRQ AKGIIVNTFL ELESRAIESF KVPPLYHVGP
     ILDVKSDGRN THPEIMQWLD DQPEGSVVFL CFGSMGSFSE DQLKEIAYAL ENSGHRFLWS
     IRRPPPPDKI ASPTDYEDPR DVLPEGFLER TVAVGKVIGW APQVAVLAHP AIGGFVSHCG
     WNSVLESLWF GVPIATWPMY AEQQFNAFEM VVELGLGVEI DMGYRKESGI IVNSDKIERA
     IRKLMENSDE KRKKVKEMRE KSKMALIDGG SSFISLGDFI KDAMEG