ID   UFOG4_MANES             Reviewed;         241 AA.
AC   Q40286;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Anthocyanidin 3-O-glucosyltransferase 4;
DE            EC=2.4.1.115;
DE   AltName: Full=Flavonol 3-O-glucosyltransferase 4;
DE   AltName: Full=UDP-glucose flavonoid 3-O-glucosyltransferase 4;
DE   Flags: Fragment;
GN   Name=GT4; Synonyms=UGT73A4;
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cotyledon;
RX   PubMed=7894058; DOI=10.3109/10425179409039703;
RA   Hughes J., Hughes M.A.;
RT   "Multiple secondary plant product UDP-glucose glucosyltransferase genes
RT   expressed in cassava (Manihot esculenta Crantz) cotyledons.";
RL   DNA Seq. 5:41-49(1994).
CC   -!- FUNCTION: In the presence of other necessary color factors, this
CC       glycosylation reaction allows the accumulation of anthocyanin pigments.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an anthocyanidin + H(+) + UDP-alpha-D-glucose = an
CC         anthocyanidin 3-O-beta-D-glucoside + UDP; Xref=Rhea:RHEA:20093,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16307, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:143576; EC=2.4.1.115;
CC   -!- PATHWAY: Pigment biosynthesis; anthocyanin biosynthesis.
CC   -!- TISSUE SPECIFICITY: Faintly expressed in cotyledons, roots and leaves.
CC   -!- DEVELOPMENTAL STAGE: Rare transcripts expressed in cotyledon and roots
CC       during the development.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X77460; CAA54610.1; -; mRNA.
DR   AlphaFoldDB; Q40286; -.
DR   SMR; Q40286; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   UniPathway; UPA00009; -.
DR   GO; GO:0047213; F:anthocyanidin 3-O-glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           <1..241
FT                   /note="Anthocyanidin 3-O-glucosyltransferase 4"
FT                   /id="PRO_0000074145"
FT   NON_TER         1
SQ   SEQUENCE   241 AA;  27068 MW;  5CAF9A821B368E29 CRC64;
     CNKLKLDKAE RGDKASVDNT ELLKWLDLWE PGSVIYACLG SISGLTSWQL AELGLGLEST
     NQPFIWVIRE GEKSEGLEKW ILEEGYEERK RKREDFWIRG WSPQVLILSH PAIGAFFTHC
     GWNSTLEGIS AGVPIVACPL FAEQFYNEKL VVEVLGIGVS VGVEAAVTWG LEDKCGAVMK
     KEQVKKAIEI VMDKGKEGEE RRRRAREIGE MAKRTIEEGG SSYLDMEMLI QYVSERSPSR
     A