ID   UFOG5_MANES             Reviewed;         487 AA.
AC   Q40287;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Anthocyanidin 3-O-glucosyltransferase 5;
DE            EC=2.4.1.115;
DE   AltName: Full=Flavonol 3-O-glucosyltransferase 5;
DE   AltName: Full=UDP-glucose flavonoid 3-O-glucosyltransferase 5;
GN   Name=GT5; Synonyms=UGT73A5;
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cotyledon;
RX   PubMed=7894058; DOI=10.3109/10425179409039703;
RA   Hughes J., Hughes M.A.;
RT   "Multiple secondary plant product UDP-glucose glucosyltransferase genes
RT   expressed in cassava (Manihot esculenta Crantz) cotyledons.";
RL   DNA Seq. 5:41-49(1994).
CC   -!- FUNCTION: In the presence of other necessary color factors, this
CC       glycosylation reaction allows the accumulation of anthocyanin pigments.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an anthocyanidin + H(+) + UDP-alpha-D-glucose = an
CC         anthocyanidin 3-O-beta-D-glucoside + UDP; Xref=Rhea:RHEA:20093,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16307, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:143576; EC=2.4.1.115;
CC   -!- PATHWAY: Pigment biosynthesis; anthocyanin biosynthesis.
CC   -!- TISSUE SPECIFICITY: Faintly expressed in cotyledons.
CC   -!- DEVELOPMENTAL STAGE: Rare transcripts expressed in cotyledon and roots
CC       during the development.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X77462; CAA54612.1; -; mRNA.
DR   PIR; S41951; S41951.
DR   AlphaFoldDB; Q40287; -.
DR   SMR; Q40287; -.
DR   STRING; 3983.cassava4.1_029183m; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PRIDE; Q40287; -.
DR   UniPathway; UPA00009; -.
DR   GO; GO:0047213; F:anthocyanidin 3-O-glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..487
FT                   /note="Anthocyanidin 3-O-glucosyltransferase 5"
FT                   /id="PRO_0000074146"
SQ   SEQUENCE   487 AA;  54382 MW;  0F5CA2EBC897F124 CRC64;
     MGSTDLNSKP HIVLLSSPGL GHLIPVLELG KRIVTLCNFD VTIFMVGSDT SAAEPQVLRS
     AMTPKLCEII QLPPPNISCL IDPEATVCTR LFVLMREIRP AFRAAVSALK FRPAAIIVDL
     FGTESLEVAK ELGIAKYVYI ASNAWFLALT IYVPILDKEV EGEFVLQKEP MKIPGCRPVR
     TEEVVDPMLD RTNQQYSEYF RLGIEIPTAD GILMNTWEAL EPTTFGALRD VKFLGRVAKV
     PVFPIGPLRR QAGPCGSNCE LLDWLDQQPK ESVVYVSFGS GGTLSLEQMI ELAWGLERSQ
     QRFIWVVRQP TVKTGDAAFF TQGDGADDMS GYFPEGFLTR IQNVGLVVPQ WSPQIHIMSH
     PSVGVFLSHC GWNSVLESIT AGVPIIAWPI YAEQRMNATL LTEELGVAVR PKNLPAKEVV
     KREEIERMIR RIMVDEEGSE IRKRVRELKD SGEKALNEGG SSFNYMSALG NEWEKSWKTQ
     RSERSLW