ID   UFOG6_MANES             Reviewed;         394 AA.
AC   Q40288;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Anthocyanidin 3-O-glucosyltransferase 6;
DE            EC=2.4.1.115;
DE   AltName: Full=Flavonol 3-O-glucosyltransferase 6;
DE   AltName: Full=UDP-glucose flavonoid 3-O-glucosyltransferase 6;
DE   Flags: Fragment;
GN   Name=GT6; Synonyms=UGT73A6;
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cotyledon;
RX   PubMed=7894058; DOI=10.3109/10425179409039703;
RA   Hughes J., Hughes M.A.;
RT   "Multiple secondary plant product UDP-glucose glucosyltransferase genes
RT   expressed in cassava (Manihot esculenta Crantz) cotyledons.";
RL   DNA Seq. 5:41-49(1994).
CC   -!- FUNCTION: In the presence of other necessary color factors, this
CC       glycosylation reaction allows the accumulation of anthocyanin pigments
CC       (By similarity). May be involved in glycosylation of unstable
CC       cyanohydrins to produce stable cyanoglucosides. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an anthocyanidin + H(+) + UDP-alpha-D-glucose = an
CC         anthocyanidin 3-O-beta-D-glucoside + UDP; Xref=Rhea:RHEA:20093,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16307, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:58885, ChEBI:CHEBI:143576; EC=2.4.1.115;
CC   -!- PATHWAY: Pigment biosynthesis; anthocyanin biosynthesis.
CC   -!- TISSUE SPECIFICITY: Expressed in cotyledons and leaves.
CC   -!- DEVELOPMENTAL STAGE: Expressed primarily in developing cotyledons (from
CC       emerging green cotyledons to approximately 10 days old); very low
CC       levels in hypocotyls and no measurable expression in roots.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X77463; CAA54613.1; -; mRNA.
DR   PIR; S41952; S41952.
DR   AlphaFoldDB; Q40288; -.
DR   SMR; Q40288; -.
DR   STRING; 3983.cassava4.1_007099m; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   UniPathway; UPA00009; -.
DR   GO; GO:0047213; F:anthocyanidin 3-O-glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           <1..394
FT                   /note="Anthocyanidin 3-O-glucosyltransferase 6"
FT                   /id="PRO_0000074147"
FT   NON_TER         1
SQ   SEQUENCE   394 AA;  44265 MW;  FD51CD974E5ADCD7 CRC64;
     DDFKDLGFID KQKAHVKEAV SKLTARSDSS LAGFVLDMFC TSMIDVAKEL GVPYYIFFTS
     GAAFLGFLFY VQLIHDEQDA DLTQFKDSDA ELSVPSLANS LPARVLPASM LVKDRFYAFI
     RIIRGLREAK GIMVNTFMEL ESHALNSLKD DQSKIPPIYP VGPILKLSNQ ENDVGPEGSE
     IIEWLDDQPP SSVVFLCFGS MGGFDMDQAK EIACALEQSR HRFLWSLRRP PPKGKIETST
     DYENLQEILP VGFSERTAGM GKVVGWAPQV AILEHPAIGG FVSHCGWNSI LESIWFSVPI
     ATWPLYAEQQ FNAFTMVTEL GLAVEIKMDY KKESEIILSA DDIERGIKCV MEHHSEIRKR
     VKEMSDKSRK ALMDDESSSF WLDRLIEDVI NNLS