UFSP1_DROME
ID UFSP1_DROME Reviewed; 234 AA.
AC Q4V6M7;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Probable Ufm1-specific protease 1;
DE Short=UfSP1;
DE EC=3.4.22.-;
GN Name=UFSP1; ORFNames=CG30157;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Thiol protease which recognizes and hydrolyzes the peptide
CC bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein
CC bound to a number of target proteins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q4V6M7; A8DYH2: Ufm1; NbExp=4; IntAct=EBI-15116415, EBI-15116417;
CC -!- SIMILARITY: Belongs to the peptidase C78 family. {ECO:0000305}.
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DR EMBL; AE013599; AAM70838.1; -; Genomic_DNA.
DR EMBL; BT022279; AAY54695.1; -; mRNA.
DR RefSeq; NP_001286151.1; NM_001299222.1.
DR RefSeq; NP_724519.1; NM_165499.2.
DR AlphaFoldDB; Q4V6M7; -.
DR SMR; Q4V6M7; -.
DR IntAct; Q4V6M7; 1.
DR STRING; 7227.FBpp0085517; -.
DR MEROPS; C78.001; -.
DR PaxDb; Q4V6M7; -.
DR PRIDE; Q4V6M7; -.
DR DNASU; 246489; -.
DR EnsemblMetazoa; FBtr0086186; FBpp0085517; FBgn0050157.
DR EnsemblMetazoa; FBtr0345010; FBpp0311261; FBgn0050157.
DR GeneID; 246489; -.
DR KEGG; dme:Dmel_CG30157; -.
DR FlyBase; FBgn0050157; CG30157.
DR VEuPathDB; VectorBase:FBgn0050157; -.
DR eggNOG; KOG2433; Eukaryota.
DR GeneTree; ENSGT00940000162936; -.
DR HOGENOM; CLU_114366_0_0_1; -.
DR InParanoid; Q4V6M7; -.
DR OMA; QTLCSWP; -.
DR OrthoDB; 444004at2759; -.
DR PhylomeDB; Q4V6M7; -.
DR BioGRID-ORCS; 246489; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 246489; -.
DR PRO; PR:Q4V6M7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0050157; Expressed in testis and 9 other tissues.
DR ExpressionAtlas; Q4V6M7; baseline and differential.
DR Genevisible; Q4V6M7; DM.
DR GO; GO:0071567; F:deUFMylase activity; ISS:UniProtKB.
DR GO; GO:0016790; F:thiolester hydrolase activity; ISS:UniProtKB.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR012462; Peptidase_C78_UfSP1/2.
DR Pfam; PF07910; Peptidase_C78; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Protease; Reference proteome; Thiol protease;
KW Ubl conjugation pathway.
FT CHAIN 1..234
FT /note="Probable Ufm1-specific protease 1"
FT /id="PRO_0000280371"
FT ACT_SITE 70
FT /evidence="ECO:0000250"
FT ACT_SITE 194
FT /evidence="ECO:0000250"
FT ACT_SITE 196
FT /evidence="ECO:0000250"
SQ SEQUENCE 234 AA; 25791 MW; 91EE4BC7D13D156C CRC64;
MAAEKCAEEF GDSSAASLKI VPKDYAYPLL EDPQGALTTP TEGGRTLVTR GGFNYFHYGC
DGHQDAGWGC GYRTLQSAIS WIQRRQGSSG HVPSIREIQQ ILVAIGDKGP EFVGSRDWIG
TLEEFYVIDV LHQVPCKILH AKELSSDEIL GELRSYFEKY QGFVAMGGLS DTASKAITGY
HCSARGRIFL QVVDPHFVGV PSSRQHLIDL GYVRWVPVDE FAGSTYNLCL ILQP
