ID   UGE1_ORYSJ              Reviewed;         354 AA.
AC   Q8LNZ3;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=UDP-glucose 4-epimerase 1;
DE            Short=OsUGE-1;
DE            EC=5.1.3.2;
DE   AltName: Full=UDP-galactose 4-epimerase 1;
GN   Name=UGE-1; OrderedLocusNames=Os05g0595100, LOC_Os05g51670;
GN   ORFNames=OsJ_19776, OSJNBa0030I14.9;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Nipponbare; TISSUE=Immature seed;
RA   Suzuki K., Kitamura S.;
RT   "Cloning of UDP-glucose 4-epimerase gene in Oryza sativa.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [7]
RP   GENE FAMILY.
RX   PubMed=16266295; DOI=10.1042/bj20051329;
RA   Zhang Q., Hrmova M., Shirley N.J., Lahnstein J., Fincher G.B.;
RT   "Gene expression patterns and catalytic properties of UDP-D-glucose 4-
RT   epimerases from barley (Hordeum vulgare L.).";
RL   Biochem. J. 394:115-124(2006).
CC   -!- FUNCTION: Catalyzes the interconversion between UDP-glucose and UDP-
CC       galactose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AB087745; BAC02925.1; -; mRNA.
DR   EMBL; AC136217; AAV59383.1; -; Genomic_DNA.
DR   EMBL; AP008211; BAF18426.1; -; Genomic_DNA.
DR   EMBL; AP014961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM000142; EEE64916.1; -; Genomic_DNA.
DR   RefSeq; XP_015640233.1; XM_015784747.1.
DR   AlphaFoldDB; Q8LNZ3; -.
DR   SMR; Q8LNZ3; -.
DR   STRING; 4530.OS05T0595100-01; -.
DR   PaxDb; Q8LNZ3; -.
DR   PRIDE; Q8LNZ3; -.
DR   EnsemblPlants; Os05t0595100-01; Os05t0595100-01; Os05g0595100.
DR   GeneID; 4339812; -.
DR   Gramene; Os05t0595100-01; Os05t0595100-01; Os05g0595100.
DR   KEGG; osa:4339812; -.
DR   eggNOG; KOG1371; Eukaryota.
DR   InParanoid; Q8LNZ3; -.
DR   OrthoDB; 662484at2759; -.
DR   BRENDA; 5.1.3.2; 8948.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000007752; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; NAD; Reference proteome.
FT   CHAIN           1..354
FT                   /note="UDP-glucose 4-epimerase 1"
FT                   /id="PRO_0000422188"
FT   ACT_SITE        157
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         8..39
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         133
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   354 AA;  38989 MW;  1E9610A9AAF83E85 CRC64;
     MVSALLRTIL VTGGAGYIGS HTVLQLLQLG FRVVVLDNLD NASELAILRV RELAGHNANN
     LDFRKVDLRD KQALDQIFSS QRFEAVIHFA GLKAVGESVQ KPLLYYDNNL IGTITLLQVM
     AAHGCTKLVF SSSATVYGWP KEVPCTEESP LCAMNPYGRT KLVIEDMCRD LHASDPNWKI
     ILLRYFNPVG AHPSGYIGED PCGIPNNLMP FVQQVAVGRR PALTVYGTDY NTKDGTGVRD
     YIHVVDLADG HIAALRKLYE DSDRIGCEVY NLGTGKGTSV LEMVAAFEKA SGKKIPLVFA
     GRRPGDAEIV YAQTAKAEKE LKWKAKYGVE EMCRDLWNWA SKNPYGYGSP DSSN