UGE2_ORYSJ
ID UGE2_ORYSJ Reviewed; 408 AA.
AC Q6ZDJ7; A0A0P0XEZ7; Q8H931;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=UDP-glucose 4-epimerase 2;
DE Short=OsUGE-2;
DE EC=5.1.3.2;
DE AltName: Full=UDP-galactose 4-epimerase 2;
GN Name=UGE-2; OrderedLocusNames=Os08g0374800, LOC_Os08g28730;
GN ORFNames=P0436B06.11;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Nipponbare; TISSUE=Immature seed;
RA Suzuki K., Kitamura S.;
RT "Cloning of UDP-glucose 4-epimerase genes in Oryza sativa.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=16266295; DOI=10.1042/bj20051329;
RA Zhang Q., Hrmova M., Shirley N.J., Lahnstein J., Fincher G.B.;
RT "Gene expression patterns and catalytic properties of UDP-D-glucose 4-
RT epimerases from barley (Hordeum vulgare L.).";
RL Biochem. J. 394:115-124(2006).
CC -!- FUNCTION: Catalyzes the interconversion between UDP-glucose and UDP-
CC galactose. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2;
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000305}.
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DR EMBL; AB096863; BAC24803.1; -; mRNA.
DR EMBL; AP004397; BAD05280.1; -; Genomic_DNA.
DR EMBL; AP008214; BAF23582.1; -; Genomic_DNA.
DR EMBL; AP014964; BAT05183.1; -; Genomic_DNA.
DR EMBL; AK066269; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015650590.1; XM_015795104.1.
DR AlphaFoldDB; Q6ZDJ7; -.
DR SMR; Q6ZDJ7; -.
DR STRING; 4530.OS08T0374800-01; -.
DR PaxDb; Q6ZDJ7; -.
DR PRIDE; Q6ZDJ7; -.
DR EnsemblPlants; Os08t0374800-01; Os08t0374800-01; Os08g0374800.
DR GeneID; 4345415; -.
DR Gramene; Os08t0374800-01; Os08t0374800-01; Os08g0374800.
DR KEGG; osa:4345415; -.
DR eggNOG; KOG1371; Eukaryota.
DR HOGENOM; CLU_007383_1_10_1; -.
DR InParanoid; Q6ZDJ7; -.
DR OMA; FDQHEIG; -.
DR OrthoDB; 662484at2759; -.
DR PlantReactome; R-OSA-1119452; Galactose degradation II.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000000763; Chromosome 8.
DR Proteomes; UP000059680; Chromosome 8.
DR Genevisible; Q6ZDJ7; OS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR01179; galE; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism; Galactose metabolism; Isomerase; NAD;
KW Reference proteome.
FT CHAIN 1..408
FT /note="UDP-glucose 4-epimerase 2"
FT /id="PRO_0000422189"
FT REGION 369..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 162
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 13..44
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 138
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 57
FT /note="A -> T (in Ref. 5; AK066269)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="N -> S (in Ref. 1; BAC24803)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="C -> W (in Ref. 1; BAC24803)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="T -> A (in Ref. 5; AK066269)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="G -> E (in Ref. 5; AK066269)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 44160 MW; CA70852FA77C4510 CRC64;
MAVEKTVPGG VRTVLVTGGA GYIGSHAVLQ LLLAGFRAVV VDNLNNSSEL AVRRVAALAG
DHSRNLAFHK VDLRDKGALE KVFASTRFDA VVHFAGLKAV GESVQKPLLY YDNNVNGTVN
LLEVMSAHGC KKLVFSSSAA VYGSPKNSPC TEEFPLTPNN PYGKTKLVVE DICRDIYRTD
PEWKIILLRY FNPVGAHPSG YLGEDPCGIP NNLMPYVQQV AVGRRPALTI LGNDYATRDG
TGVRDYIHVV DLADGHIAAL QKLFESSSIG CEAYNLGTGK GTSVLEIVKA FEKASGKKIP
LIIGPRRPGD AEILFSLPAK AEKELNWKAK FGIDEMCRDQ WNWASKNPYG YGSLDSTKQN
GHHSYGSIGS PKQNGHCTNG FSESTRHNGH NGYGLVDSAK HNGNGHFH
