UGE3_ORYSJ
ID UGE3_ORYSJ Reviewed; 373 AA.
AC Q652A8; A0A0P0XQ27; Q8H0B7;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=UDP-glucose 4-epimerase 3;
DE Short=OsUGE-3;
DE EC=5.1.3.2;
DE AltName: Full=UDP-galactose 4-epimerase 3;
GN Name=UGE-3; OrderedLocusNames=Os09g0526700, LOC_Os09g35800;
GN ORFNames=OJ1439_F07.18, OsJ_30076;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Nipponbare; TISSUE=Immature seed;
RA Suzuki K., Kitamura S.;
RT "Cloning of UDP-glucose 4-epimerase genes in Oryza sativa.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP GENE FAMILY.
RX PubMed=16266295; DOI=10.1042/bj20051329;
RA Zhang Q., Hrmova M., Shirley N.J., Lahnstein J., Fincher G.B.;
RT "Gene expression patterns and catalytic properties of UDP-D-glucose 4-
RT epimerases from barley (Hordeum vulgare L.).";
RL Biochem. J. 394:115-124(2006).
CC -!- FUNCTION: Catalyzes the interconversion between UDP-glucose and UDP-
CC galactose. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2;
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC41499.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB097460; BAC41499.1; ALT_INIT; mRNA.
DR EMBL; AP005681; BAD46359.1; -; Genomic_DNA.
DR EMBL; AP008215; BAF25641.1; -; Genomic_DNA.
DR EMBL; AP014965; BAT09056.1; -; Genomic_DNA.
DR EMBL; CM000146; EEE70082.1; -; Genomic_DNA.
DR EMBL; AK073610; BAG93548.1; -; mRNA.
DR EMBL; AK104977; BAG97056.1; -; mRNA.
DR RefSeq; XP_015610723.1; XM_015755237.1.
DR AlphaFoldDB; Q652A8; -.
DR SMR; Q652A8; -.
DR STRING; 4530.OS09T0526700-01; -.
DR PaxDb; Q652A8; -.
DR PRIDE; Q652A8; -.
DR EnsemblPlants; Os09t0526700-01; Os09t0526700-01; Os09g0526700.
DR EnsemblPlants; Os09t0526700-02; Os09t0526700-02; Os09g0526700.
DR GeneID; 4347638; -.
DR Gramene; Os09t0526700-01; Os09t0526700-01; Os09g0526700.
DR Gramene; Os09t0526700-02; Os09t0526700-02; Os09g0526700.
DR KEGG; osa:4347638; -.
DR eggNOG; KOG1371; Eukaryota.
DR HOGENOM; CLU_007383_1_10_1; -.
DR InParanoid; Q652A8; -.
DR OMA; KVMTGQY; -.
DR OrthoDB; 662484at2759; -.
DR PlantReactome; R-OSA-1119452; Galactose degradation II.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000000763; Chromosome 9.
DR Proteomes; UP000007752; Chromosome 9.
DR Proteomes; UP000059680; Chromosome 9.
DR Genevisible; Q652A8; OS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR01179; galE; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism; Galactose metabolism; Isomerase; NAD;
KW Reference proteome.
FT CHAIN 1..373
FT /note="UDP-glucose 4-epimerase 3"
FT /id="PRO_0000422190"
FT ACT_SITE 177
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 27..58
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 153
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 156
FT /note="V -> A (in Ref. 1; BAC41499)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="N -> D (in Ref. 1; BAC41499)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 373 AA; 40386 MW; 90EA744A6128A889 CRC64;
MVSGGGVAAE NGEMVGNGEG RKGAGASVLV TGGAGYIGTH TVLRLLEKGF AVTVVDNFHN
SVPEALDRVR LIAGAALSAR LDFIAGDLKS KDDMEKVFAA KRYDAVIHFA GLKAVGESVA
HPQMYYENNV AGTMNLYSAM TKYGCKKIVF SSSATVYGQP EKTPCVEDSK LSALNPYGTT
KLVLENYFRQ VQAADPEMRV ILLRYFNPIG AHRSGDIGED PRGIPNNLLP YIQQVAVGRR
PELNVYGVDY PTRDGTAIRD YIHVVDLADG HIAALEKLFA TPDIGCVAYN LGTGCGTTVL
EVVKAFEEAS GKKIPIKICP RRPGDCTEVY ASTDKAKKEL GWSARFGIED MCRDQWNWAK
KNPYGYSANA EQN
