CA122_HUMAN
ID CA122_HUMAN Reviewed; 110 AA.
AC Q6ZSJ8; A2RQF4; E9PQ13; Q56A71;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Uncharacterized protein C1orf122;
DE AltName: Full=Protein ALAESM;
GN Name=C1orf122;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Subthalamic nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Chen S., Guo J.H., Yu L.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZSJ8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZSJ8-2; Sequence=VSP_046648;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=BAC86950.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AK127381; BAC86950.1; ALT_SEQ; mRNA.
DR EMBL; AY517499; AAS76640.1; -; mRNA.
DR EMBL; AL929472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057819; AAH57819.1; ALT_SEQ; mRNA.
DR CCDS; CCDS427.2; -. [Q6ZSJ8-1]
DR CCDS; CCDS44112.1; -. [Q6ZSJ8-2]
DR RefSeq; NP_001136198.1; NM_001142726.1. [Q6ZSJ8-2]
DR RefSeq; NP_940848.2; NM_198446.2. [Q6ZSJ8-1]
DR AlphaFoldDB; Q6ZSJ8; -.
DR SMR; Q6ZSJ8; -.
DR BioGRID; 126077; 15.
DR IntAct; Q6ZSJ8; 10.
DR STRING; 9606.ENSP00000362133; -.
DR GlyGen; Q6ZSJ8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6ZSJ8; -.
DR PhosphoSitePlus; Q6ZSJ8; -.
DR BioMuta; C1orf122; -.
DR EPD; Q6ZSJ8; -.
DR jPOST; Q6ZSJ8; -.
DR MassIVE; Q6ZSJ8; -.
DR MaxQB; Q6ZSJ8; -.
DR PaxDb; Q6ZSJ8; -.
DR PeptideAtlas; Q6ZSJ8; -.
DR PRIDE; Q6ZSJ8; -.
DR ProteomicsDB; 22883; -.
DR ProteomicsDB; 68221; -. [Q6ZSJ8-1]
DR TopDownProteomics; Q6ZSJ8-1; -. [Q6ZSJ8-1]
DR Antibodypedia; 54370; 51 antibodies from 11 providers.
DR DNASU; 127687; -.
DR Ensembl; ENST00000373042.5; ENSP00000362133.4; ENSG00000197982.14. [Q6ZSJ8-1]
DR Ensembl; ENST00000373043.1; ENSP00000362134.1; ENSG00000197982.14. [Q6ZSJ8-2]
DR Ensembl; ENST00000468084.1; ENSP00000434520.1; ENSG00000197982.14. [Q6ZSJ8-2]
DR GeneID; 127687; -.
DR KEGG; hsa:127687; -.
DR MANE-Select; ENST00000373042.5; ENSP00000362133.4; NM_198446.3; NP_940848.2.
DR UCSC; uc001ccd.3; human. [Q6ZSJ8-1]
DR CTD; 127687; -.
DR GeneCards; C1orf122; -.
DR HGNC; HGNC:24789; C1orf122.
DR HPA; ENSG00000197982; Low tissue specificity.
DR neXtProt; NX_Q6ZSJ8; -.
DR OpenTargets; ENSG00000197982; -.
DR PharmGKB; PA142672440; -.
DR VEuPathDB; HostDB:ENSG00000197982; -.
DR eggNOG; ENOG502TDYG; Eukaryota.
DR GeneTree; ENSGT00570000079623; -.
DR HOGENOM; CLU_3175232_0_0_1; -.
DR InParanoid; Q6ZSJ8; -.
DR OMA; LRWNGAP; -.
DR OrthoDB; 1560404at2759; -.
DR PathwayCommons; Q6ZSJ8; -.
DR SignaLink; Q6ZSJ8; -.
DR BioGRID-ORCS; 127687; 8 hits in 1048 CRISPR screens.
DR ChiTaRS; C1orf122; human.
DR GenomeRNAi; 127687; -.
DR Pharos; Q6ZSJ8; Tdark.
DR PRO; PR:Q6ZSJ8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6ZSJ8; protein.
DR Bgee; ENSG00000197982; Expressed in C1 segment of cervical spinal cord and 177 other tissues.
DR Genevisible; Q6ZSJ8; HS.
DR InterPro; IPR031714; DUF4726.
DR PANTHER; PTHR41401; PTHR41401; 1.
DR Pfam; PF15855; DUF4726; 1.
PE 4: Predicted;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..110
FT /note="Uncharacterized protein C1orf122"
FT /id="PRO_0000254193"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 36..68
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046648"
SQ SEQUENCE 110 AA; 11471 MW; C63352FB57850CFE CRC64;
MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR QRQLLDTIAA
CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP KDAGDGAAEP
