ID   UGL_BURA4               Reviewed;         282 AA.
AC   B1Z1Y2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ureidoglycolate lyase;
DE            Short=UGL;
DE            EC=4.3.2.3;
DE   AltName: Full=Ureidoglycolase;
DE   AltName: Full=Ureidoglycolatase;
DE   AltName: Full=Ureidoglycolate hydrolase;
GN   OrderedLocusNames=BamMC406_5393;
OS   Burkholderia ambifaria (strain MC40-6).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=398577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC40-6;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Ramette A.,
RA   Konstantinidis K., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia ambifaria MC40-6.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC   -!- PATHWAY: Purine metabolism; urate degradation.
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; CP001026; ACB67837.1; -; Genomic_DNA.
DR   RefSeq; WP_012367054.1; NC_010552.1.
DR   AlphaFoldDB; B1Z1Y2; -.
DR   SMR; B1Z1Y2; -.
DR   PRIDE; B1Z1Y2; -.
DR   EnsemblBacteria; ACB67837; ACB67837; BamMC406_5393.
DR   KEGG; bac:BamMC406_5393; -.
DR   HOGENOM; CLU_028458_3_4_4; -.
DR   OMA; YVSQCMS; -.
DR   OrthoDB; 775108at2; -.
DR   UniPathway; UPA00394; -.
DR   Proteomes; UP000001680; Chromosome 2.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   3: Inferred from homology;
KW   Lyase; Metal-binding; Nucleotide metabolism.
FT   CHAIN           1..282
FT                   /note="Ureidoglycolate lyase"
FT                   /id="PRO_0000371513"
FT   BINDING         124
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         126
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         155
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30221 MW;  CE51241437A4F7A8 CRC64;
     MKLLRYGPSG QEKPGILDAD GRIRDLSAHV PDLAGDVLSD AALARLRAID PATLPLVSGE
     PRIGACVGRV GKFIGIGLNY ADHAAEAGMP VPKEPVVFGK WTSSICGPND GIDIPKGSVK
     TDWEVELGVV IGTTCKDVDE ARALDYVAGY CVVNDVSERE WQIERGGQWD KGKGFDTFGP
     IGPWLVTRDE VPDPQRVDLW LEIDGHRYQN GNTRTMVFTV AQLVAYLSTC MTLQPGDVIT
     TGTPPGVGMG IKPSPVFLKA GQTVRLGIDG LGEQLQSTRN AQ