ID   UGL_BURCJ               Reviewed;         282 AA.
AC   B4EKX6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Ureidoglycolate lyase;
DE            Short=UGL;
DE            EC=4.3.2.3;
DE   AltName: Full=Ureidoglycolase;
DE   AltName: Full=Ureidoglycolatase;
DE   AltName: Full=Ureidoglycolate hydrolase;
GN   OrderedLocusNames=BceJ2315_61450; ORFNames=BCAM2707;
OS   Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS   NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=216591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610;
RX   PubMed=18931103; DOI=10.1128/jb.01230-08;
RA   Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA   Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA   Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA   Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA   Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA   Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT   "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT   cystic fibrosis patients.";
RL   J. Bacteriol. 191:261-277(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-ureidoglycolate = glyoxylate + urea; Xref=Rhea:RHEA:11304,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:36655, ChEBI:CHEBI:57296; EC=4.3.2.3;
CC   -!- PATHWAY: Purine metabolism; urate degradation.
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000305}.
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DR   EMBL; AM747721; CAR56571.1; -; Genomic_DNA.
DR   RefSeq; WP_006481667.1; NC_011001.1.
DR   AlphaFoldDB; B4EKX6; -.
DR   SMR; B4EKX6; -.
DR   STRING; 216591.BCAM2707; -.
DR   EnsemblBacteria; CAR56571; CAR56571; BCAM2707.
DR   GeneID; 56563231; -.
DR   KEGG; bcj:BCAM2707; -.
DR   eggNOG; COG0179; Bacteria.
DR   HOGENOM; CLU_028458_3_4_4; -.
DR   OMA; YVSQCMS; -.
DR   OrthoDB; 775108at2; -.
DR   BioCyc; BCEN216591:G1G1V-6820-MON; -.
DR   UniPathway; UPA00394; -.
DR   Proteomes; UP000001035; Chromosome 2.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   3: Inferred from homology;
KW   Lyase; Metal-binding; Nucleotide metabolism.
FT   CHAIN           1..282
FT                   /note="Ureidoglycolate lyase"
FT                   /id="PRO_0000371512"
FT   BINDING         124
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         126
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
FT   BINDING         155
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  30247 MW;  65DD4E9A87FCBB3F CRC64;
     MKLLRYGPPG QEKPGILDAA GRIRDLSAHV PDLAGEVLSD AGLARLRAID PATLPLVSGE
     PRIGACVGHV GKFIGIGLNY ADHAAEAGMP VPKEPVVFGK WTSSICGPND GIDIPKGSVK
     TDWEVELGVV IGAKCKDVDE ARALDYVAGY CVVNDVSERE WQIERGGQWD KGKGFDTFGP
     IGPWLVTRDE VPDPQRLDLW LEIDGHRYQN GNTRTMVFTV AQLIAYLSTC MTLQPGDVIT
     TGTPPGVGMG IKPSPVFLKA GQMVRLGIDG LGEQLQSTRH AQ