UGO1_SCHPO
ID UGO1_SCHPO Reviewed; 421 AA.
AC Q9UTF8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Mitochondrial fusion and transport protein ugo1;
GN Name=ugo1; ORFNames=SPAC1B2.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for mitochondrial fusion as well as normal
CC mitochondrial morphology. May coordinate fusion of inner and outer
CC membranes during mitochondrial fusion (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB61469.1; -; Genomic_DNA.
DR PIR; T50138; T50138.
DR RefSeq; NP_593929.1; NM_001019358.2.
DR AlphaFoldDB; Q9UTF8; -.
DR STRING; 4896.SPAC1B2.02c.1; -.
DR iPTMnet; Q9UTF8; -.
DR MaxQB; Q9UTF8; -.
DR PaxDb; Q9UTF8; -.
DR EnsemblFungi; SPAC1B2.02c.1; SPAC1B2.02c.1:pep; SPAC1B2.02c.
DR GeneID; 2542501; -.
DR KEGG; spo:SPAC1B2.02c; -.
DR PomBase; SPAC1B2.02c; ugo1.
DR VEuPathDB; FungiDB:SPAC1B2.02c; -.
DR eggNOG; ENOG502RQI2; Eukaryota.
DR HOGENOM; CLU_029376_1_0_1; -.
DR InParanoid; Q9UTF8; -.
DR OMA; KTILQVY; -.
DR PhylomeDB; Q9UTF8; -.
DR PRO; PR:Q9UTF8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008053; P:mitochondrial fusion; ISO:PomBase.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 1.
DR SUPFAM; SSF103506; SSF103506; 2.
DR PROSITE; PS50920; SOLCAR; 2.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..421
FT /note="Mitochondrial fusion and transport protein ugo1"
FT /id="PRO_0000362157"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 117..200
FT /note="Solcar 1"
FT REPEAT 215..310
FT /note="Solcar 2"
FT REPEAT 318..419
FT /note="Solcar 3"
FT REGION 77..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 46910 MW; E6102902EF9E44C6 CRC64;
MNPYRPYVVV NNVEPTFSIT PEPTFETQPT ISKSEIFETL RSILVTKYLT TFFVQPLEVA
KTVCQVEEYL PKRTKIERDG KQTKEPYDED IPDGTEQEGL SDDEHEIYAY FETPTTEKAV
TEQLAEKLCV DASGYVTDPS NLIERSYTIH SKRFSIKSII SELWEKEGAR GLWKGHTISF
LHNLLYSGLQ SWLSATLSGA LAIADPNIIS PIDSVRPLLS LFIKSITSAI SALILSPLDI
ARTKIILFPI SSSSYLSSAS ETSGNSHKKF KPLTIRQCLK ALPFYCPSSL ILPTVCYVSL
PPFVSSVLPL TFRNFLGSSP TLDAMVGLGT SAVQFLLKCP LEMVLRRAQA QYECNLPPQT
IVPVGKYTGI VGTIWCLLSE EDPGKFGIEG LYRGWRVGIW GMSSTLALNY ISSNLREEVE
F
