UGPC_SALTY
ID UGPC_SALTY Reviewed; 356 AA.
AC Q8ZLF4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=sn-glycerol-3-phosphate import ATP-binding protein UgpC {ECO:0000255|HAMAP-Rule:MF_01727};
DE EC=7.6.2.10 {ECO:0000255|HAMAP-Rule:MF_01727};
GN Name=ugpC {ECO:0000255|HAMAP-Rule:MF_01727}; OrderedLocusNames=STM3554;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP POSSIBLE FUNCTION IN SN-GLYCEROL-3-PHOSPHATE TRANSPORT.
RC STRAIN=LT2;
RX PubMed=6408060; DOI=10.1128/jb.155.1.186-195.1983;
RA Hengge R., Larson T.J., Boos W.;
RT "sn-glycerol-3-phosphate transport in Salmonella typhimurium.";
RL J. Bacteriol. 155:186-195(1983).
CC -!- FUNCTION: Part of the ABC transporter complex UgpABCE involved in sn-
CC glycerol-3-phosphate import. Responsible for energy coupling to the
CC transport system (Probable). {ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) +
CC phosphate + sn-glycerol 3-phosphate(in); Xref=Rhea:RHEA:21668,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC EC=7.6.2.10; Evidence={ECO:0000255|HAMAP-Rule:MF_01727};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (UgpC),
CC two transmembrane proteins (UgpA and UgpE) and a solute-binding protein
CC (UgpB). {ECO:0000255|HAMAP-Rule:MF_01727}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01727}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01727}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. sn-glycerol-3-
CC phosphate importer (TC 3.A.1.1.3) family. {ECO:0000255|HAMAP-
CC Rule:MF_01727}.
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DR EMBL; AE006468; AAL22414.1; -; Genomic_DNA.
DR RefSeq; NP_462455.1; NC_003197.2.
DR RefSeq; WP_000907838.1; NC_003197.2.
DR AlphaFoldDB; Q8ZLF4; -.
DR SMR; Q8ZLF4; -.
DR STRING; 99287.STM3554; -.
DR PaxDb; Q8ZLF4; -.
DR EnsemblBacteria; AAL22414; AAL22414; STM3554.
DR GeneID; 1255077; -.
DR KEGG; stm:STM3554; -.
DR PATRIC; fig|99287.12.peg.3757; -.
DR HOGENOM; CLU_000604_1_1_6; -.
DR OMA; PRNMYDK; -.
DR PhylomeDB; Q8ZLF4; -.
DR BioCyc; SENT99287:STM3554-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IBA:GO_Central.
DR GO; GO:0015430; F:ABC-type glycerol-3-phosphate transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015794; P:glycerol-3-phosphate transmembrane transport; IBA:GO_Central.
DR GO; GO:0001407; P:glycerophosphodiester transmembrane transport; IBA:GO_Central.
DR CDD; cd03301; ABC_MalK_N; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015855; ABC_transpr_MalK-like.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR040582; OB_MalK.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR017922; UgpC.
DR PANTHER; PTHR43875:SF12; PTHR43875:SF12; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17912; OB_MalK; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51315; UGPC; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Sugar transport; Translocase;
KW Transport.
FT CHAIN 1..356
FT /note="sn-glycerol-3-phosphate import ATP-binding protein
FT UgpC"
FT /id="PRO_0000289781"
FT DOMAIN 4..235
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01727"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01727"
SQ SEQUENCE 356 AA; 39476 MW; 82918343A4ABC805 CRC64;
MAGLKLQAVT KSWDGKTQVI QPLTLDVADG EFIVMVGPSG CGKSTLLRMV AGLERVTSGD
IWIDRKRVTE MEPKDRGIAM VFQNYALYPH MSVEENMAWG LKIRGMSKAH IEERVREAAR
ILELDGLLKR RPRELSGGQR QRVAMGRAIV REPAVFLFDE PLSNLDAKLR VQMRLELQHL
HRRLRTTSLY VTHDQVEAMT LAQRVMVMNK GVAEQIGTPV EVYEKPASRF VASFIGSPAM
NLLDGVISAS GDRFELPGGL ALPIGADYRG HAGRNMTLGI RPEHIALSSQ AEGGVPLTVD
TLEILGADNL AHGRWGDQKL VVRLAHQQRP AAGSTLWLHL PEHQRHLFDG ETGQRV
