ID   UGPE_ECOLI              Reviewed;         281 AA.
AC   P10906; Q2M7B4;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=sn-glycerol-3-phosphate transport system permease protein UgpE;
GN   Name=ugpE; OrderedLocusNames=b3451, JW3416;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=3062310; DOI=10.1111/j.1365-2958.1988.tb00088.x;
RA   Overduin P., Boos W., Tommassen J.;
RT   "Nucleotide sequence of the ugp genes of Escherichia coli K-12: homology to
RT   the maltose system.";
RL   Mol. Microbiol. 2:767-775(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       sn-glycerol-3-phosphate; probably responsible for the translocation of
CC       the substrate across the membrane.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (UgpC),
CC       two transmembrane proteins (UgpA and UgpE) and a solute-binding protein
CC       (UgpB). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC       {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. UgpAE subfamily. {ECO:0000305}.
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DR   EMBL; X13141; CAA31533.1; -; Genomic_DNA.
DR   EMBL; U00039; AAB18426.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76476.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77842.1; -; Genomic_DNA.
DR   PIR; S03782; MMECUE.
DR   RefSeq; NP_417908.1; NC_000913.3.
DR   RefSeq; WP_000572177.1; NZ_LN832404.1.
DR   AlphaFoldDB; P10906; -.
DR   SMR; P10906; -.
DR   BioGRID; 4261664; 250.
DR   ComplexPortal; CPX-2150; sn-glycerol-3-phosphate ABC transporter complex.
DR   IntAct; P10906; 1.
DR   STRING; 511145.b3451; -.
DR   TCDB; 3.A.1.1.3; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P10906; -.
DR   PRIDE; P10906; -.
DR   EnsemblBacteria; AAC76476; AAC76476; b3451.
DR   EnsemblBacteria; BAE77842; BAE77842; BAE77842.
DR   GeneID; 947959; -.
DR   KEGG; ecj:JW3416; -.
DR   KEGG; eco:b3451; -.
DR   PATRIC; fig|1411691.4.peg.3276; -.
DR   EchoBASE; EB1042; -.
DR   eggNOG; COG0395; Bacteria.
DR   HOGENOM; CLU_016047_1_1_6; -.
DR   InParanoid; P10906; -.
DR   OMA; IAFFIAW; -.
DR   PhylomeDB; P10906; -.
DR   BioCyc; EcoCyc:UGPE-MON; -.
DR   BioCyc; MetaCyc:UGPE-MON; -.
DR   BRENDA; 7.6.2.10; 2026.
DR   PRO; PR:P10906; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IDA:EcoCyc.
DR   GO; GO:1902517; C:glycerol-3-phosphate-transporting ATPase complex; IPI:ComplexPortal.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IDA:ComplexPortal.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0015169; F:glycerol-3-phosphate transmembrane transporter activity; IDA:EcoCyc.
DR   GO; GO:0015794; P:glycerol-3-phosphate transmembrane transport; IDA:ComplexPortal.
DR   GO; GO:0001407; P:glycerophosphodiester transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR030165; UgpE.
DR   PANTHER; PTHR43744:SF8; PTHR43744:SF8; 1.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..281
FT                   /note="sn-glycerol-3-phosphate transport system permease
FT                   protein UgpE"
FT                   /id="PRO_0000060233"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          77..268
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   281 AA;  31500 MW;  16CEE371D329C10B CRC64;
     MIENRPWLTI FSHTMLILGI AVILFPLYVA FVAATLDKQA VYAAPMTLIP GTHLLENIHN
     IWVNGVGTNS APFWRMLLNS FVMAFSITLG KITVSMLSAF AIVWFRFPLR NLFFWMIFIT
     LMLPVEVRIF PTVEVIANLQ MLDSYAGLTL PLMASATATF LFRQFFMTLP DELVEAARID
     GASPMRFFCD IVFPLSKTNL AALFVITFIY GWNQYLWPLL IITDVDLGTT VAGIKGMIAT
     GEGTTEWNSV MVAMLLTLIP PVVIVLVMQR AFVRGLVDSE K