ID   UGT3_PLEPL              Reviewed;         472 AA.
AC   Q91280;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=UDP-glucuronosyltransferase;
DE            Short=UDPGT;
DE            EC=2.4.1.17;
DE   Flags: Fragment;
GN   Name=ugt3;
OS   Pleuronectes platessa (European plaice).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Pleuronectes.
OX   NCBI_TaxID=8262;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Pirrit L., Healey R., Assheton H., Leaver M.J., George S.G.;
RT   "Cloning of the major 3-MC inducible phase I and phase II detoxification
RT   enzymes of plaice liver.";
RL   Mar. Environ. Res. 39:15-19(1995).
CC   -!- FUNCTION: UDPGT is of major importance in the conjugation and
CC       subsequent elimination of potentially toxic xenobiotics and endogenous
CC       compounds.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; X74116; CAA52214.1; -; mRNA.
DR   AlphaFoldDB; Q91280; -.
DR   SMR; Q91280; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane;
KW   Microsome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..472
FT                   /note="UDP-glucuronosyltransferase"
FT                   /id="PRO_0000074137"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        227
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        377
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   472 AA;  53781 MW;  CCCC44363B54643B CRC64;
     LVPESSLFMH QSEDYETEVY PVSFTTEEMD ATHKQLKDGL FLKQPDWTEY YVNIMRFVNF
     TSIHLRGCEN LLENQPLMSR MRGMGFDIVL TDPFFPCGAL VGNIFSIPVV NFLRGLPCGL
     DMKVNKCPSP PSYIPVPYSG NTNIMTFPQR VINMAMTVVE SYQCSLLYGH YDEMVSKYVG
     NNMDYRTLLS HGALWLIRNE FTLDWPRPLL PNMVLIGGIN CAEKKKNASL PADLEEFVQG
     SGDDGFIIFT LGSMLPDMPQ EKAQHFLDAF RQIPQRVVWR YAGDPPKGLP KNVRLMKWLP
     QKELLAHPKA KLFLTHGGSH SVYEGICNAV PMLMFPLFAE QGDNGLRMVT RGAAETLNIY
     DVTSDNLLAA LNKILKNKSY KEKITEMSQI HHDRPVAPLD LAIFWTEFVI RHKGASHLRV
     AAHELNWIQY HSLDVFGFIL LILLTVLWVT LKCCLFCTRR CCRRGTAKTK SE