UGT56_CAEEL
ID UGT56_CAEEL Reviewed; 524 AA.
AC Q22181;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 11-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Putative UDP-glucuronosyltransferase ugt-56;
DE Short=UDPGT 56;
DE EC=2.4.1.17;
DE Flags: Precursor;
GN Name=ugt-56; Synonyms=ugt12; ORFNames=T04H1.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000305}.
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DR EMBL; Z78200; CAB01585.2; -; Genomic_DNA.
DR PIR; T24478; T24478.
DR RefSeq; NP_506074.2; NM_073673.4.
DR AlphaFoldDB; Q22181; -.
DR SMR; Q22181; -.
DR STRING; 6239.T04H1.8; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR PaxDb; Q22181; -.
DR PRIDE; Q22181; -.
DR EnsemblMetazoa; T04H1.8.1; T04H1.8.1; WBGene00011453.
DR GeneID; 188073; -.
DR KEGG; cel:CELE_T04H1.8; -.
DR UCSC; T04H1.8; c. elegans.
DR CTD; 188073; -.
DR WormBase; T04H1.8; CE31985; WBGene00011453; ugt-56.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00970000196326; -.
DR HOGENOM; CLU_012949_1_2_1; -.
DR InParanoid; Q22181; -.
DR OMA; VYFTARI; -.
DR OrthoDB; 508327at2759; -.
DR PhylomeDB; Q22181; -.
DR Reactome; R-CEL-1660662; Glycosphingolipid metabolism.
DR Reactome; R-CEL-9753281; Paracetamol ADME.
DR PRO; PR:Q22181; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011453; Expressed in larva and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR Pfam; PF00201; UDPGT; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal;
KW Transferase; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..524
FT /note="Putative UDP-glucuronosyltransferase ugt-56"
FT /id="PRO_0000036052"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 335
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 524 AA; 59284 MW; 2CDA85E24BBDF3CC CRC64;
MLWAFIVWLG ALCIYGSAFD ILIYAPRMMQ SHVYFTARIA NVLAARGHKV TVIDNVFRYD
VDNELSSDIH EIISVEPSPE VTKLLNTGSL PTILWNSKAS PEEQRTIMEG LGHVHRLQCT
HLIENSTLIP KLQEIKFDFA IHEVFDSCGV GILEVIGVQK TVIVSSTGPM DVVPITLGIS
DTLNTPSLLS DYGSYLSFFE KRRNLKFLSG MLNFHEMQDS MISPLFKKYY GLKKPTGEIM
RQANLLFYNI HEGSDGMRMR GRRSFDIGGI AFKDQKNLTM EYQTLLSDPR PKVLVSFGTA
ATSSHMPQNL KNSLMTAMKQ MNNVLFIWKY EMEDNFTKQE ELTTNIIFKK FLPQTDLLAS
SKIDLFVTHC GQNSLLEAFN SGVRVLAVPL FGDQHRNAKL AFENGLIEIL PKSDIETPAK
IVKAVKTGLE PNAKLDQNIV LISSLLRNSK ENAENLLIST IEATYSTEFP PNFSKFPKNY
HPNTLVRLID SSIALVFMLF IFVFVNHFRK NYVGFKYPLS FSTK