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UGT56_CAEEL
ID   UGT56_CAEEL             Reviewed;         524 AA.
AC   Q22181;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Putative UDP-glucuronosyltransferase ugt-56;
DE            Short=UDPGT 56;
DE            EC=2.4.1.17;
DE   Flags: Precursor;
GN   Name=ugt-56; Synonyms=ugt12; ORFNames=T04H1.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; Z78200; CAB01585.2; -; Genomic_DNA.
DR   PIR; T24478; T24478.
DR   RefSeq; NP_506074.2; NM_073673.4.
DR   AlphaFoldDB; Q22181; -.
DR   SMR; Q22181; -.
DR   STRING; 6239.T04H1.8; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PaxDb; Q22181; -.
DR   PRIDE; Q22181; -.
DR   EnsemblMetazoa; T04H1.8.1; T04H1.8.1; WBGene00011453.
DR   GeneID; 188073; -.
DR   KEGG; cel:CELE_T04H1.8; -.
DR   UCSC; T04H1.8; c. elegans.
DR   CTD; 188073; -.
DR   WormBase; T04H1.8; CE31985; WBGene00011453; ugt-56.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00970000196326; -.
DR   HOGENOM; CLU_012949_1_2_1; -.
DR   InParanoid; Q22181; -.
DR   OMA; VYFTARI; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; Q22181; -.
DR   Reactome; R-CEL-1660662; Glycosphingolipid metabolism.
DR   Reactome; R-CEL-9753281; Paracetamol ADME.
DR   PRO; PR:Q22181; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00011453; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..524
FT                   /note="Putative UDP-glucuronosyltransferase ugt-56"
FT                   /id="PRO_0000036052"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        125
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        277
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        335
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   524 AA;  59284 MW;  2CDA85E24BBDF3CC CRC64;
     MLWAFIVWLG ALCIYGSAFD ILIYAPRMMQ SHVYFTARIA NVLAARGHKV TVIDNVFRYD
     VDNELSSDIH EIISVEPSPE VTKLLNTGSL PTILWNSKAS PEEQRTIMEG LGHVHRLQCT
     HLIENSTLIP KLQEIKFDFA IHEVFDSCGV GILEVIGVQK TVIVSSTGPM DVVPITLGIS
     DTLNTPSLLS DYGSYLSFFE KRRNLKFLSG MLNFHEMQDS MISPLFKKYY GLKKPTGEIM
     RQANLLFYNI HEGSDGMRMR GRRSFDIGGI AFKDQKNLTM EYQTLLSDPR PKVLVSFGTA
     ATSSHMPQNL KNSLMTAMKQ MNNVLFIWKY EMEDNFTKQE ELTTNIIFKK FLPQTDLLAS
     SKIDLFVTHC GQNSLLEAFN SGVRVLAVPL FGDQHRNAKL AFENGLIEIL PKSDIETPAK
     IVKAVKTGLE PNAKLDQNIV LISSLLRNSK ENAENLLIST IEATYSTEFP PNFSKFPKNY
     HPNTLVRLID SSIALVFMLF IFVFVNHFRK NYVGFKYPLS FSTK
 
 
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