ID   UGT58_CAEEL             Reviewed;         533 AA.
AC   Q20086;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Putative UDP-glucuronosyltransferase ugt-58;
DE            Short=UDPGT 58;
DE            EC=2.4.1.17;
DE   Flags: Precursor;
GN   Name=ugt-58; Synonyms=ugt5; ORFNames=F35H8.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; Z36752; CAA85328.2; -; Genomic_DNA.
DR   PIR; T21823; T21823.
DR   RefSeq; NP_496059.2; NM_063658.6.
DR   AlphaFoldDB; Q20086; -.
DR   SMR; Q20086; -.
DR   BioGRID; 39830; 1.
DR   STRING; 6239.F35H8.6; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   EPD; Q20086; -.
DR   PaxDb; Q20086; -.
DR   PeptideAtlas; Q20086; -.
DR   PRIDE; Q20086; -.
DR   EnsemblMetazoa; F35H8.6.1; F35H8.6.1; WBGene00009450.
DR   GeneID; 174507; -.
DR   KEGG; cel:CELE_F35H8.6; -.
DR   UCSC; F35H8.6; c. elegans.
DR   CTD; 174507; -.
DR   WormBase; F35H8.6; CE00984; WBGene00009450; ugt-58.
DR   eggNOG; KOG1192; Eukaryota.
DR   HOGENOM; CLU_012949_3_2_1; -.
DR   InParanoid; Q20086; -.
DR   OMA; RKDTFWP; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; Q20086; -.
DR   Reactome; R-CEL-1660662; Glycosphingolipid metabolism.
DR   Reactome; R-CEL-9753281; Paracetamol ADME.
DR   PRO; PR:Q20086; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00009450; Expressed in material anatomical entity and 5 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..533
FT                   /note="Putative UDP-glucuronosyltransferase ugt-58"
FT                   /id="PRO_0000036050"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        243
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        336
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   533 AA;  61143 MW;  B094511E73D55D46 CRC64;
     MKSWLLLLGT IGWVTAGDVL FIPSTLYPVH AQTMSVLARE LAERGHKVTW LEIGPERSDI
     VLHQQVSREF WPAQFGDRTL QEIYQFKNHT SHSELWNPQY TNENEQTTGW LASIRLCDSV
     LSRSKSKFDK MVEKQFSTVI VDDLYNSCGV LMAGLKKSVY IYWSMTGLRT ESAWANQSPS
     PPSYLPVAGT GLTDDLTFSQ RLYNVASYFK QLYIHQHIVQ PRIDAVFQKY YPGVESTFEI
     ERNASINFVN TPPIFDFSRP YMPRVNFIGA IQCRKPKELP KEFTSWISAY PDGFVVLSTG
     FTVQWNKSPE HIRQAYLDTF KYLPNLLFIW QTGLPNSSNL PSNLLVKPWL PLQDLLGHQK
     CRCHVSHGGL NSVIESVYHG VPVVGVPLTS RGYDNLLRIT ARDSGVMVEK SEFSGEILTA
     AINEVIENEK YKKEMLIFQD MVIDVPYTEL YHAAFWVEFI ERHQEVPHAR SGADHLNFLQ
     YFLVDVIAFF FFVIFCTLSI IYYTIRTVFR TIRSVVNGVR GVPKIVSRGK KNN