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UGT5_DACCO
ID   UGT5_DACCO              Reviewed;         526 AA.
AC   A0A291PQF1;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=UDP-glycosyltransferase UGT5 {ECO:0000305};
DE            EC=2.4.1.- {ECO:0000305};
DE   AltName: Full=UDP-glucosyltransferase 5 {ECO:0000303|PubMed:29215010};
DE            Short=DcUGT5 {ECO:0000303|PubMed:29215010};
GN   Name=UGT5 {ECO:0000303|PubMed:29215010};
OS   Dactylopius coccus (Cochineal).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Coccoidea;
OC   Dactylopiidae; Dactylopius.
OX   NCBI_TaxID=765876 {ECO:0000312|EMBL:ATL15306.1};
RN   [1] {ECO:0000312|EMBL:ATL15306.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=29215010; DOI=10.1038/s41467-017-02031-z;
RA   Kannangara R., Siukstaite L., Borch-Jensen J., Madsen B., Kongstad K.T.,
RA   Staerk D., Bennedsen M., Okkels F.T., Rasmussen S.A., Larsen T.O.,
RA   Frandsen R.J.N., Moeller B.L.;
RT   "Characterization of a membrane-bound C-glucosyltransferase responsible for
RT   carminic acid biosynthesis in Dactylopius coccus Costa.";
RL   Nat. Commun. 8:1987-1987(2017).
CC   -!- FUNCTION: Catalyzes the transfer of a glycosyl group from a UDP-sugar
CC       to an acceptor molecule. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:29215010};
CC       Single-pass type I membrane protein {ECO:0000305|PubMed:29215010}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in adult female.
CC       {ECO:0000269|PubMed:29215010}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000255|RuleBase:RU003718}.
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DR   EMBL; KY860727; ATL15306.1; -; mRNA.
DR   AlphaFoldDB; A0A291PQF1; -.
DR   SMR; A0A291PQF1; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane;
KW   Microsome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..526
FT                   /note="UDP-glycosyltransferase UGT5"
FT                   /id="PRO_0000450687"
FT   TOPO_DOM        1..474
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        496..526
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        124
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        283
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   526 AA;  60071 MW;  CA8E44327A7D8853 CRC64;
     MIFFYFLTLT SFISVAFSYN ILGVFPFQAK SHFGFIDPLL VRLAELGHNV TIYDPYPKSE
     KLPNYNEIDV SECFVFNTLY EEIDTFIKTA ASPFSSLWYS FEETLAVFQK ENFDKCAPLR
     ELLNSTVKYD LLITETFLTD ITLLFVNKFK IPFITSTPNV PFPWLADRMG NPLNPSYIPN
     LFSDYPFDKM TFFNRLWNTL FYVMALGGHN AIILKNEEKI NKYYFGSSVP SLYNIARETS
     IMLINAHETL NPVIPLVPGM IPVSGIHIKQ PAALPQNIEK FINESTHGVV YFCMGSLLRG
     ETFPAEKRDA FLYAFSKIPQ RVLWKWEGEV LPGKSENIMT SKWMPQRDIL AHPNVKLFIS
     HGGLLGTSEA VYEGVPVIGI PIFGDQRTNI KALEANGAGE LLDYNDISGE VVLEKIQRLI
     NDPKYKESAR QLSIRYKDRP MSPLDTAVYW TEYVIRHKGA PHLKTAAVDM PWYQYLLLDV
     IAFLIFILVS VILIIYYGVK ISLRYLCALI FGNSSSLKPT KKVKDN
 
 
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