ID   UGT60_CAEEL             Reviewed;         507 AA.
AC   P34317;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Putative UDP-glucuronosyltransferase ugt-60;
DE            Short=UDPGT 60;
DE            EC=2.4.1.17;
DE   Flags: Precursor;
GN   Name=ugt-60; ORFNames=C07A9.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; Z29094; CAA82344.2; -; Genomic_DNA.
DR   PIR; S40710; S40710.
DR   RefSeq; NP_001021158.1; NM_001025987.3.
DR   AlphaFoldDB; P34317; -.
DR   SMR; P34317; -.
DR   BioGRID; 41561; 1.
DR   IntAct; P34317; 1.
DR   STRING; 6239.C07A9.6; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   EPD; P34317; -.
DR   PaxDb; P34317; -.
DR   PeptideAtlas; P34317; -.
DR   EnsemblMetazoa; C07A9.6.1; C07A9.6.1; WBGene00007402.
DR   GeneID; 176366; -.
DR   KEGG; cel:CELE_C07A9.6; -.
DR   UCSC; C07A9.6; c. elegans.
DR   CTD; 176366; -.
DR   WormBase; C07A9.6; CE33970; WBGene00007402; ugt-60.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00940000164145; -.
DR   HOGENOM; CLU_012949_1_3_1; -.
DR   InParanoid; P34317; -.
DR   OMA; RVIWITH; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; P34317; -.
DR   Reactome; R-CEL-1660662; Glycosphingolipid metabolism.
DR   Reactome; R-CEL-9753281; Paracetamol ADME.
DR   PRO; PR:P34317; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007402; Expressed in material anatomical entity and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..507
FT                   /note="Putative UDP-glucuronosyltransferase ugt-60"
FT                   /id="PRO_0000036067"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        312
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   507 AA;  57727 MW;  BE91C2F305B4FAE6 CRC64;
     MYLPIFCIFL SVVDSLRILQ IVPGFTNSHV LFNYRLAETL RFLGHDVKMW TQMEMAMLDT
     GNNKLPEGVS EYRIPIHFTD TLKTEGLKVF QSMMFESGDA HDLWWTGQEF KDMRVEACEQ
     MLRHDESVYE DFRKDGFDVA IAHFHDLCPL AIAKKMNVKR VIWITHGTSI YEFSAVQLGL
     RTIPSTIPHP LSSAGFSQLF LDRVQNTLWH LSLLDFVNLP QNLLVDENLF YREFVGADQD
     DLWDLAKTTV PSLLINGDRM LDFPRPLPIH IAFSGELGVS KGKKLVMEKW LEDIIEKPSD
     GLIVFSLGTV SNTTNMPAQM INSFLGAFGK LKTYTILWRM EKSVAGAEKY ENLHLVKWLP
     QKDIMRHPKM KLMIAHGGYN SFLEAAQAGI PAVLMPLFAD QKINAKRAQR YGMATVLDKL
     DLTINNVYGA IKEALKPEYS TNAKKLSAML SDQVARKPYS ALRYSLKLAT SPKPSLFTLK
     SQHLSFLEFH NLDIFSIVLL TAFIVCF