CA131_HUMAN
ID CA131_HUMAN Reviewed; 293 AA.
AC Q8NDD1; Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q96NM6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized protein C1orf131;
GN Name=C1orf131; Synonyms=cPERP-A {ECO:0000303|PubMed:20813266};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-28.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP VAL-28.
RC TISSUE=Eye, Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-163, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-185, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [8]
RP SUBCELLULAR LOCATION.
RX PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L., Wood L.,
RA Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P., Fukagawa T.,
RA Earnshaw W.C., Rappsilber J.;
RT "The protein composition of mitotic chromosomes determined using
RT multiclassifier combinatorial proteomics.";
RL Cell 142:810-821(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-78 AND SER-279, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-279, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8NDD1-6; P55040: GEM; NbExp=3; IntAct=EBI-17761821, EBI-744104;
CC Q8NDD1-6; Q92993: KAT5; NbExp=3; IntAct=EBI-17761821, EBI-399080;
CC Q8NDD1-6; Q9NQZ2: UTP3; NbExp=3; IntAct=EBI-17761821, EBI-714067;
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:20813266}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NDD1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDD1-5; Sequence=VSP_059469;
CC Name=3;
CC IsoId=Q8NDD1-6; Sequence=VSP_059467;
CC Name=4;
CC IsoId=Q8NDD1-7; Sequence=VSP_059466, VSP_059468;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-11 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK055124; BAB70857.1; -; mRNA.
DR EMBL; AL834274; CAD38949.2; -; Transcribed_RNA.
DR EMBL; AL137801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036800; AAH36800.2; -; mRNA.
DR EMBL; BC053609; AAH53609.1; -; mRNA.
DR EMBL; BC062353; AAH62353.1; -; mRNA.
DR CCDS; CCDS1591.2; -. [Q8NDD1-1]
DR CCDS; CCDS73049.1; -. [Q8NDD1-6]
DR RefSeq; NP_001287759.1; NM_001300830.1. [Q8NDD1-6]
DR RefSeq; NP_689592.2; NM_152379.3. [Q8NDD1-1]
DR PDB; 7MQ8; EM; 3.60 A; NE=1-293.
DR PDB; 7MQ9; EM; 3.87 A; NE=1-293.
DR PDBsum; 7MQ8; -.
DR PDBsum; 7MQ9; -.
DR AlphaFoldDB; Q8NDD1; -.
DR SMR; Q8NDD1; -.
DR BioGRID; 126091; 54.
DR IntAct; Q8NDD1; 16.
DR MINT; Q8NDD1; -.
DR STRING; 9606.ENSP00000355609; -.
DR GlyGen; Q8NDD1; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8NDD1; -.
DR PhosphoSitePlus; Q8NDD1; -.
DR SwissPalm; Q8NDD1; -.
DR BioMuta; C1orf131; -.
DR DMDM; 146286060; -.
DR EPD; Q8NDD1; -.
DR jPOST; Q8NDD1; -.
DR MassIVE; Q8NDD1; -.
DR MaxQB; Q8NDD1; -.
DR PaxDb; Q8NDD1; -.
DR PeptideAtlas; Q8NDD1; -.
DR PRIDE; Q8NDD1; -.
DR ProteomicsDB; 73015; -. [Q8NDD1-1]
DR Antibodypedia; 34684; 65 antibodies from 15 providers.
DR DNASU; 128061; -.
DR Ensembl; ENST00000366649.7; ENSP00000355609.2; ENSG00000143633.13. [Q8NDD1-1]
DR Ensembl; ENST00000366651.7; ENSP00000355611.3; ENSG00000143633.13. [Q8NDD1-6]
DR GeneID; 128061; -.
DR KEGG; hsa:128061; -.
DR MANE-Select; ENST00000366649.7; ENSP00000355609.2; NM_152379.4; NP_689592.2.
DR UCSC; uc001hul.4; human. [Q8NDD1-1]
DR CTD; 128061; -.
DR GeneCards; C1orf131; -.
DR HGNC; HGNC:25332; C1orf131.
DR HPA; ENSG00000143633; Low tissue specificity.
DR neXtProt; NX_Q8NDD1; -.
DR OpenTargets; ENSG00000143633; -.
DR PharmGKB; PA142672449; -.
DR VEuPathDB; HostDB:ENSG00000143633; -.
DR eggNOG; ENOG502S2E3; Eukaryota.
DR GeneTree; ENSGT00390000017022; -.
DR InParanoid; Q8NDD1; -.
DR OMA; EVVQFHS; -.
DR OrthoDB; 1536903at2759; -.
DR PhylomeDB; Q8NDD1; -.
DR TreeFam; TF328381; -.
DR PathwayCommons; Q8NDD1; -.
DR SignaLink; Q8NDD1; -.
DR BioGRID-ORCS; 128061; 413 hits in 1053 CRISPR screens.
DR ChiTaRS; C1orf131; human.
DR GenomeRNAi; 128061; -.
DR Pharos; Q8NDD1; Tdark.
DR PRO; PR:Q8NDD1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NDD1; protein.
DR Bgee; ENSG00000143633; Expressed in ileal mucosa and 171 other tissues.
DR ExpressionAtlas; Q8NDD1; baseline and differential.
DR Genevisible; Q8NDD1; HS.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR027973; DUF4602.
DR Pfam; PF15375; DUF4602; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Chromosome;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..293
FT /note="Uncharacterized protein C1orf131"
FT /id="PRO_0000285029"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 163
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT MOD_RES 185
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT VAR_SEQ 151..166
FT /note="QANPSVLERDVDTQEF -> VMSWLAYIYVVNPLVL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059466"
FT VAR_SEQ 151
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_059467"
FT VAR_SEQ 167..293
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059468"
FT VAR_SEQ 248
FT /note="D -> DR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_059469"
FT VARIANT 28
FT /note="L -> V (in dbSNP:rs2274067)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_031906"
FT CONFLICT 103
FT /note="S -> P (in Ref. 1; BAB70857)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 32610 MW; D045FE659BA8C659 CRC64;
MRVDSSADPT MSQEQGPGSS TPPSSPTLLD ALLQNLYDFG GTEGETEQKK IIKKRENKKR
DVMASAALAA EPSPLPGSLI RGQRKSASSF FKELREERHC APSGTPTGPE ILAAAVPPSS
LKNNREQVEV VEFHSNKKRK LTPDHNKNTK QANPSVLERD VDTQEFNLEK ARLEVHRFGI
TGYGKGKERI LEQERAIMLG AKPPKKSYVN YKVLQEQIKE KKAAKEEEKR LAQETDIFKK
KKRKGQEDRK SKKKSAPSIL SNGRIGQVGK FKNGTLILSP VDIKKINSSR VAK
