UGTP1_CAEEL
ID UGTP1_CAEEL Reviewed; 355 AA.
AC Q02334; P34632;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=UDP-galactose translocator 1;
GN Name=ugtp-1; ORFNames=ZK370.7/ZK370.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=17913784; DOI=10.1242/dev.011361;
RA Bembenek J.N., Richie C.T., Squirrell J.M., Campbell J.M., Eliceiri K.W.,
RA Poteryaev D., Spang A., Golden A., White J.G.;
RT "Cortical granule exocytosis in C. elegans is regulated by cell cycle
RT components including separase.";
RL Development 134:3837-3848(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cytoplasmic granule membrane
CC {ECO:0000269|PubMed:17913784}. Note=Localizes to cortical granules
CC during meiotic prometaphase I and metaphase I.
CC {ECO:0000269|PubMed:17913784}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000305}.
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DR EMBL; FO080164; CCD61726.1; -; Genomic_DNA.
DR PIR; S44668; S44668.
DR RefSeq; NP_498930.1; NM_066529.5.
DR AlphaFoldDB; Q02334; -.
DR SMR; Q02334; -.
DR BioGRID; 41430; 1.
DR STRING; 6239.ZK370.7; -.
DR PaxDb; Q02334; -.
DR PeptideAtlas; Q02334; -.
DR PRIDE; Q02334; -.
DR EnsemblMetazoa; ZK370.7.1; ZK370.7.1; WBGene00022721.
DR EnsemblMetazoa; ZK370.7.2; ZK370.7.2; WBGene00022721.
DR GeneID; 176227; -.
DR KEGG; cel:CELE_ZK370.7; -.
DR CTD; 176227; -.
DR WormBase; ZK370.7; CE29642; WBGene00022721; ugtp-1.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR HOGENOM; CLU_024645_1_0_1; -.
DR InParanoid; Q02334; -.
DR OMA; KCYVIAS; -.
DR OrthoDB; 703674at2759; -.
DR PhylomeDB; Q02334; -.
DR PRO; PR:Q02334; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022721; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0060473; C:cortical granule; IDA:WormBase.
DR GO; GO:0005797; C:Golgi medial cisterna; IDA:WormBase.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; PTHR10231; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..355
FT /note="UDP-galactose translocator 1"
FT /id="PRO_0000213364"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 39893 MW; 62ED33CA61340C73 CRC64;
MKFQNVHISH QDEDKEKLLP NDKDVEKADE SPSSSRPSFV FKCYVIASMT FIWTAYTLTI
KYTRSTVNPD MMYSSTSVVL CAEILKLVIT FAMFYKECNF DSRQFSEQVS KYYINAPREL
AKMSVPSFAY ALQNNLDFVG LSNLDAGLYQ VTTQLKVVST AFFMMLFLGR KFSTRRWMAI
TLLMFGVAFV QMNNVSASEA NTKRETAENY IVGLSAVLAT CVTAGFAGVY FEKMLKDGGS
TPFWIRNMQM YSCGVISASI ACLTDFSRIS DKGFFFGYTD KVWAVVILLG VGGLYISLVM
RYLDNLYKSM ASAVSIILVV VLSMLIFPDI FIGMYFVLGT ICVVLAVLLY NSVNE
