UH1BL_MOUSE
ID UH1BL_MOUSE Reviewed; 1457 AA.
AC A2RSJ4; B2RQV0; E9QMH4; Q8CHD4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=UHRF1-binding protein 1-like {ECO:0000312|MGI:MGI:2442888};
DE AltName: Full=Syntaxin-6 Habc-interacting protein of 164 kDa {ECO:0000250|UniProtKB:A0JNW5};
GN Name=Uhrf1bp1l {ECO:0000312|MGI:MGI:2442888};
GN Synonyms=Kiaa0701 {ECO:0000312|EMBL:BAC41445.1},
GN Ship164 {ECO:0000250|UniProtKB:A0JNW5};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 9:179-188(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1008, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774; SER-934 AND SER-1008,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Homodimer (via N-terminus). Associates with the Golgi-
CC associated retrograde protein (GARP) complex. Interacts with GARP
CC complex component VPS52. Interacts (via C-terminal coiled-coil domain)
CC with STX6. {ECO:0000250|UniProtKB:A0JNW5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:A0JNW5}. Early endosome
CC {ECO:0000250|UniProtKB:A0JNW5}. Note=Primarily cytosolic. Recruited to
CC early endosomes following STX6 overexpression. Overexpression of both
CC STX6 and UHRF1BP1L results in aberrant tubulation of endosomal
CC membranes. {ECO:0000250|UniProtKB:A0JNW5}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC41445.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB093261; BAC41445.1; ALT_INIT; mRNA.
DR EMBL; AC130216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC134539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132134; AAI32135.1; -; mRNA.
DR EMBL; BC138092; AAI38093.1; -; mRNA.
DR CCDS; CCDS36028.1; -.
DR RefSeq; NP_083442.2; NM_029166.2.
DR AlphaFoldDB; A2RSJ4; -.
DR BioGRID; 217211; 4.
DR IntAct; A2RSJ4; 2.
DR STRING; 10090.ENSMUSP00000020112; -.
DR iPTMnet; A2RSJ4; -.
DR PhosphoSitePlus; A2RSJ4; -.
DR EPD; A2RSJ4; -.
DR jPOST; A2RSJ4; -.
DR MaxQB; A2RSJ4; -.
DR PaxDb; A2RSJ4; -.
DR PeptideAtlas; A2RSJ4; -.
DR PRIDE; A2RSJ4; -.
DR ProteomicsDB; 298471; -.
DR Antibodypedia; 30285; 138 antibodies from 25 providers.
DR Ensembl; ENSMUST00000020112; ENSMUSP00000020112; ENSMUSG00000019951.
DR GeneID; 75089; -.
DR KEGG; mmu:75089; -.
DR UCSC; uc007gsv.2; mouse.
DR CTD; 23074; -.
DR MGI; MGI:2442888; Uhrf1bp1l.
DR VEuPathDB; HostDB:ENSMUSG00000019951; -.
DR eggNOG; KOG2955; Eukaryota.
DR GeneTree; ENSGT00600000084428; -.
DR HOGENOM; CLU_004782_0_0_1; -.
DR InParanoid; A2RSJ4; -.
DR OMA; AGDSCDH; -.
DR OrthoDB; 64302at2759; -.
DR PhylomeDB; A2RSJ4; -.
DR TreeFam; TF314874; -.
DR Reactome; R-MMU-9696270; RND2 GTPase cycle.
DR BioGRID-ORCS; 75089; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Uhrf1bp1l; mouse.
DR PRO; PR:A2RSJ4; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; A2RSJ4; protein.
DR Bgee; ENSMUSG00000019951; Expressed in submandibular gland and 240 other tissues.
DR ExpressionAtlas; A2RSJ4; baseline and differential.
DR Genevisible; A2RSJ4; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005769; C:early endosome; ISO:MGI.
DR GO; GO:0062069; F:GARP complex binding; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR InterPro; IPR026728; UHRF1BP1-like.
DR InterPro; IPR026854; VPS13-like_N.
DR PANTHER; PTHR22774; PTHR22774; 1.
DR Pfam; PF12624; Chorein_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Endosome; Phosphoprotein; Reference proteome.
FT CHAIN 1..1457
FT /note="UHRF1-binding protein 1-like"
FT /id="PRO_0000295720"
FT DOMAIN 3..94
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT REGION 267..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1410..1455
FT /evidence="ECO:0000255"
FT COMPBIAS 273..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 414
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A0JNW5"
FT MOD_RES 418
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A0JNW5"
FT MOD_RES 774
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 934
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1008
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT CONFLICT 848
FT /note="I -> T (in Ref. 1; BAC41445 and 3; AAI32135/
FT AAI38093)"
FT /evidence="ECO:0000305"
FT CONFLICT 861
FT /note="I -> V (in Ref. 1; BAC41445 and 3; AAI32135/
FT AAI38093)"
FT /evidence="ECO:0000305"
FT CONFLICT 1171
FT /note="E -> D (in Ref. 1; BAC41445 and 3; AAI32135/
FT AAI38093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1457 AA; 161940 MW; 9C93797CA1035EEF CRC64;
MAGIIKKQIL KHLSRFTKNL SPDKINLSTL KGEGELKNLE LDEEVLQNML DLPTWLAISK
VFCNKASIRI PWTKLKTQPI CLSLDKVIME MSTCEEPRAP NGPSPIATAS GQSEYGFAEK
VVEGITVSVN SIVIRIGAKA FNASFELSQL RIYSVNAQWE HGDLRFTRIQ DPQRGEVLTF
KEINWQMIRI EADATQSSHL EIMCAPVRLI TNQSKIRVTL KRRLKDCNVI ATKLVLILDD
LLWVLTDSQL KAMVQYAKSL SEAIEKSTEQ RKSMAPEPTQ SSTVTSSAQH VKTPQAANAP
DLSDAIVKLF NDFDVKETSH HLVISHLDLH ICDDIHAKEK ESNRRVSGGA MQLSFTQLTI
DYYPYHKAGD SCSHWMYFSD ATKTKNGWAN ELLHEFECNV EMLKQAMKDR NLGSPPKSPT
HASPQHTQTE KDSTLKGTPK TPSVLPQPSK AKLMSSSVVV RLADFNIYQV STAEQCRSSP
KSMISCNKKS LYLPQEMSAI YIEFTEYYYP DGKDFPIPSP NLYSQLNALQ FTVDERSILW
LNQFLLDLKQ SLNQFMAVYK LNDSSKSDEH VDIRVDGLML KFVIPSEVKA GCHQDQPHTV
SIQSSEMIAT NTRHCPNCRH SDLEALCQDF KECDFFSKTY TRFPKSCDSF NLLHPIFQRH
AHEQDTKMHE VYKGNIIPKL NKNTLKTSAA TDVWAVYFSQ FWIDYEGMKS GKGRPVSFVD
AFPLSIWICQ PTRYAELQKE FQTCDQVTLN TSQSESSDLA GRMKRKKLLK EYYSTESEPL
TNGGQRPSSD TFLRFSSSSS DADVHVLVRV HKHVSMQINH YQYLLLLFIH ESLVLLSDTL
RRDVEAVIGS PASQTSVCVG ILLRSAELAL LLHPVNPTSA LRSPASESGS PLLPDFLPAE
NGGFLSSKRK QGGSGIHRIR NATLNHMSDN RSMSVDLSHA PLKDPLLFKS ASDTNLQKGT
SFLDYLSDKH LGKISEDESS GLSHKSGSGE MTSEGSHTKD VASTDSDSVL NYRDGSTRLS
LDDDGNHNPP SNPVTGKGID AIHSIFRAED FLPEAASLSE NPESSKEEAP PARAPKSQTS
LSAKSKERCP PSPAPLSVSY KNMKRSASQV SLDTLSLDSM VLEEQAESDG SDSHVLLGKA
MKRNSNTSCQ SPAESVNTSA NTQTCGEASP EAVSTNSEGT QENRDDLMSV VVFRITGVNG
EIDIRGEDTE VCLQVNQVTP SQLGNVSLRH YLGNRPVGSD QKAIIHPKSS PEISLRFESG
PGAVVHSLLA EKNGFLQCHI ENFTTEFLTS SLLNIQHFLE DETVATVMPM KIQVSNTKIN
LKDDSPRGST VSLQPSPVTV HIDRLVVERS DDGSFHIRDS HLFNTGTDFK DGASSDSVVR
TRGMCDVRMH SSVTQATQTS PEVPLPSQSA NFLDITREQL MEENECLRQR LAQAKMELAE
AHSARDELLH QMKRMGL
