CA13_CONLT
ID CA13_CONLT Reviewed; 64 AA.
AC Q2I2R6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Alpha-conotoxin-like Lt1.3 {ECO:0000303|PubMed:16908117};
DE AltName: Full=Lt1c;
DE Flags: Precursor;
OS Conus litteratus (Lettered cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX NCBI_TaxID=89445;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA Dong M., Chen S., Xu A.;
RT "Diversity and evolution of conotoxins based on gene expression profiling
RT of Conus litteratus.";
RL Genomics 88:809-819(2006).
CC -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By
CC similarity). Has possibly a distinct nAChR binding mode from other
CC alpha-conotoxins, due to a different three residue motif (lacks the
CC Ser-Xaa-Pro motif) (By similarity). {ECO:0000250|UniProtKB:Q2I2R8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16908117}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:16908117}.
CC -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR EMBL; DQ345366; ABC74974.1; -; mRNA.
DR AlphaFoldDB; Q2I2R6; -.
DR ConoServer; 1152; Lt1C precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 3: Inferred from homology;
KW Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..45
FT /evidence="ECO:0000305|PubMed:16908117"
FT /id="PRO_0000315421"
FT PEPTIDE 46..64
FT /note="Alpha-conotoxin-like Lt1.3"
FT /evidence="ECO:0000305|PubMed:16908117"
FT /id="PRO_0000315422"
FT REGION 49..51
FT /note="Lacks the Ser-Xaa-Pro motif that is crucial for
FT potent interaction with nAChR"
FT /evidence="ECO:0000305"
FT DISULFID 47..53
FT /evidence="ECO:0000250|UniProtKB:P56636"
FT DISULFID 48..61
FT /evidence="ECO:0000250|UniProtKB:P56636"
SQ SEQUENCE 64 AA; 7500 MW; 5D03046C35525358 CRC64;
MGMRMMFTMF LLVVLTTTVV SFNLDRESNH ENRRTSNQIT RGMWDECCDD PPCRQNNMEH
CPAS