ID   UHPA_ECO57              Reviewed;         196 AA.
AC   P0AGA8; P10940;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Transcriptional regulatory protein UhpA {ECO:0000250|UniProtKB:P0AGA6};
GN   Name=uhpA; OrderedLocusNames=Z5159, ECs4606;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Part of the UhpABC signaling cascade that controls the
CC       expression of the hexose phosphate transporter UhpT. Activates the
CC       transcription of the uhpT gene. Acts by binding specifically to the
CC       uhpT promoter region. {ECO:0000250|UniProtKB:P0AGA6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and dephosphorylated by UhpB.
CC       {ECO:0000250|UniProtKB:P0AGA6}.
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DR   EMBL; AE005174; AAG58868.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38029.1; -; Genomic_DNA.
DR   PIR; F91204; F91204.
DR   PIR; H86050; H86050.
DR   RefSeq; NP_312633.1; NC_002695.1.
DR   RefSeq; WP_000633668.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AGA8; -.
DR   SMR; P0AGA8; -.
DR   STRING; 155864.EDL933_4993; -.
DR   EnsemblBacteria; AAG58868; AAG58868; Z5159.
DR   EnsemblBacteria; BAB38029; BAB38029; ECs_4606.
DR   GeneID; 66672434; -.
DR   GeneID; 915428; -.
DR   KEGG; ece:Z5159; -.
DR   KEGG; ecs:ECs_4606; -.
DR   PATRIC; fig|386585.9.peg.4814; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_000445_90_1_6; -.
DR   OMA; HPMWRDG; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..196
FT                   /note="Transcriptional regulatory protein UhpA"
FT                   /id="PRO_0000081258"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   196 AA;  20889 MW;  8F409F8AADE08276 CRC64;
     MITVALIDDH LIVRSGFAQL LGLEPDLQVV AEFGSGREAL AGLPGRGVQV CICDISMPDI
     SGLELLSQLP KGMATIMLSV HDSPALVEQA LNAGARGFLS KRCSPDELIA AVHTVATGGC
     YLTPDIAIKL ASGRQDPLTK RERQVAEKLA QGMAVKEIAA ELGLSPKTVH VHRANLMEKL
     GVSNDVELAR RMFDGW