ID   UHPA_SALTY              Reviewed;         196 AA.
AC   P27667;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Transcriptional regulatory protein UhpA {ECO:0000250|UniProtKB:P0AGA6};
GN   Name=uhpA; OrderedLocusNames=STM3790;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1569007; DOI=10.1128/jb.174.9.2754-2762.1992;
RA   Island M.D., Wei B.-Y., Kadner R.J.;
RT   "Structure and function of the uhp genes for the sugar phosphate transport
RT   system in Escherichia coli and Salmonella typhimurium.";
RL   J. Bacteriol. 174:2754-2762(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Part of the UhpABC signaling cascade that controls the
CC       expression of the hexose phosphate transporter UhpT. Activates the
CC       transcription of the uhpT gene. Acts by binding specifically to the
CC       uhpT promoter region. {ECO:0000250|UniProtKB:P0AGA6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and dephosphorylated by UhpB.
CC       {ECO:0000250|UniProtKB:P0AGA6}.
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DR   EMBL; M89480; AAA27243.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22648.1; -; Genomic_DNA.
DR   PIR; A41853; A41853.
DR   RefSeq; NP_462689.1; NC_003197.2.
DR   RefSeq; WP_000633676.1; NC_003197.2.
DR   AlphaFoldDB; P27667; -.
DR   SMR; P27667; -.
DR   STRING; 99287.STM3790; -.
DR   PaxDb; P27667; -.
DR   EnsemblBacteria; AAL22648; AAL22648; STM3790.
DR   GeneID; 1255314; -.
DR   KEGG; stm:STM3790; -.
DR   PATRIC; fig|99287.12.peg.4010; -.
DR   HOGENOM; CLU_000445_90_1_6; -.
DR   OMA; HPMWRDG; -.
DR   PhylomeDB; P27667; -.
DR   BioCyc; SENT99287:STM3790-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..196
FT                   /note="Transcriptional regulatory protein UhpA"
FT                   /id="PRO_0000081260"
FT   DOMAIN          3..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   196 AA;  20790 MW;  4C80FF931C69078F CRC64;
     MITVALIDDH LIVRSGFAQL LGLEPDLQVV AEFGSGREAL AGLPGRGVQV CICDISMPDI
     SGLELLSQLP KGMATIVLSV HDSPALVEQA LNAGARGFLS KRCSPDELIA AVHTVATGGC
     YLTPDIAVKL AAGRQDPLTK RERQVAEKLA QGMAVKEIAA ELGLSPKTVH VHRANLLEKL
     GVSNDVELAH RMFDGW