UHPC_SALTY
ID UHPC_SALTY Reviewed; 442 AA.
AC P27669;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Membrane sensor protein UhpC {ECO:0000250|UniProtKB:P09836};
GN Name=uhpC; OrderedLocusNames=STM3788;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=1569007; DOI=10.1128/jb.174.9.2754-2762.1992;
RA Island M.D., Wei B.-Y., Kadner R.J.;
RT "Structure and function of the uhp genes for the sugar phosphate transport
RT system in Escherichia coli and Salmonella typhimurium.";
RL J. Bacteriol. 174:2754-2762(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Part of the UhpABC signaling cascade that controls the
CC expression of the hexose phosphate transporter UhpT. UhpC senses
CC external glucose-6-phosphate and interacts with the histidine kinase
CC UhpB, leading to the stimulation of the autokinase activity of UhpB.
CC {ECO:0000250|UniProtKB:P09836}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P09836}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR EMBL; M89480; AAA27245.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22646.1; -; Genomic_DNA.
DR PIR; C41853; C41853.
DR RefSeq; NP_462687.1; NC_003197.2.
DR RefSeq; WP_000948173.1; NC_003197.2.
DR AlphaFoldDB; P27669; -.
DR SMR; P27669; -.
DR STRING; 99287.STM3788; -.
DR PaxDb; P27669; -.
DR EnsemblBacteria; AAL22646; AAL22646; STM3788.
DR GeneID; 1255312; -.
DR KEGG; stm:STM3788; -.
DR PATRIC; fig|99287.12.peg.4008; -.
DR HOGENOM; CLU_001265_31_0_6; -.
DR OMA; NAWFQGW; -.
DR PhylomeDB; P27669; -.
DR BioCyc; SENT99287:STM3788-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; IBA:GO_Central.
DR GO; GO:0015760; P:glucose-6-phosphate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR021159; Sugar-P_transporter_CS.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS00942; GLPT; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..442
FT /note="Membrane sensor protein UhpC"
FT /id="PRO_0000199882"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..66
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..121
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 122..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..289
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..347
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..410
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..442
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P09836"
SQ SEQUENCE 442 AA; 48255 MW; B328C365F2D0A41A CRC64;
MLSFLKAPAN APLITDKHEV DARYRYWRRH ILITIWLGYA LFYFTRKSFN AAAPEILASG
ILTRSDIGLL ATLFYITYGV SKFVSGIVSD RSNARYFMGI GLIATGVVNI LFGFSTSLWA
FALLWALNAF FQGFGSPVCA RLLTAWYSRT ERGGWWALWN TAHNVGGALI PLVMAAVALH
YGWRVGMMVA GLLAIGVGMV LCWRLRDRPQ AIGLPPVGDW RHDALEVAQQ QEGAGLSRKE
ILAKYVLLNP YIWLLSLCYV LVYVVRAAIN DWGNLYMSET LGVDLVTANT AVSMFELGGF
IGALVAGWGS DKLFNGNRGP MNLIFAAGIL LSVGSLWLMP FASYVMQAAC FFTTGFFVFG
PQMLIGMAAA ECSHKEAAGA ATGFVGLFAY LGASLSGWPL AKVLEIWHWT GFFAVIAIAA
GISALLLLPF LNAQAPRETH EA
