UIDB_ECOLI
ID UIDB_ECOLI Reviewed; 457 AA.
AC P0CE44; P30868; P77457;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Glucuronide carrier protein homolog;
GN Name=uidB; Synonyms=gusB, uidP; OrderedLocusNames=b1616, JW1608;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP LACK OF TRANSPORT IN MG1655.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15774881; DOI=10.1128/jb.187.7.2377-2385.2005;
RA Liang W.-J., Wilson K.J., Xie H., Knol J., Suzuki S., Rutherford N.G.,
RA Henderson P.J.F., Jefferson R.A.;
RT "The gusBC genes of Escherichia coli encode a glucuronide transport
RT system.";
RL J. Bacteriol. 187:2377-2385(2005).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC family. {ECO:0000305}.
CC -!- CAUTION: The protein is inactive for transport, probably due to the
CC presence of a Leu instead of a Pro at position 100. {ECO:0000305}.
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DR EMBL; U00096; AAC74688.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15367.1; -; Genomic_DNA.
DR PIR; B64918; B64918.
DR RefSeq; NP_416133.1; NC_000913.3.
DR RefSeq; WP_001075849.1; NZ_LN832404.1.
DR AlphaFoldDB; P0CE44; -.
DR SMR; P0CE44; -.
DR BioGRID; 4260252; 11.
DR STRING; 511145.b1616; -.
DR PaxDb; P0CE44; -.
DR EnsemblBacteria; AAC74688; AAC74688; b1616.
DR EnsemblBacteria; BAA15367; BAA15367; BAA15367.
DR GeneID; 947484; -.
DR KEGG; ecj:JW1608; -.
DR KEGG; eco:b1616; -.
DR PATRIC; fig|1411691.4.peg.645; -.
DR EchoBASE; EB1610; -.
DR eggNOG; COG2211; Bacteria.
DR HOGENOM; CLU_027408_0_1_6; -.
DR InParanoid; P0CE44; -.
DR OMA; RYVSGMI; -.
DR PhylomeDB; P0CE44; -.
DR BioCyc; EcoCyc:UIDB-MON; -.
DR BioCyc; MetaCyc:UIDB-MON; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001927; Na/Gal_symport.
DR InterPro; IPR018043; Na/Gal_symport_CS.
DR PANTHER; PTHR11328; PTHR11328; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00792; gph; 1.
DR PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..457
FT /note="Glucuronide carrier protein homolog"
FT /id="PRO_0000170762"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..37
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..108
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..180
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..263
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..320
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..408
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 430..457
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 457 AA; 49908 MW; 3A42E978FDB53F04 CRC64;
MNQQLSWRTI VGYSLGDVAN NFAFAMGALF LLSYYTDVAG VGAAAAGTML LLVRVFDAFA
DVFAGRVVDS VNTRWGKFRP FLLFGTAPLM IFSVLVFWVL TDWSHGSKVV YAYLTYMGLG
LCYSLVNIPY GSLATAMTQQ PQSRARLGAA RGIAASLTFV CLAFLIGPSI KNSSPEEMVS
VYHFWTIVLA IAGMVLYFIC FKSTRENVVR IVAQPSLNIS LQTLKRNRPL FMLCIGALCV
LISTFAVSAS SLFYVRYVLN DTGLFTVLVL VQNLVGTVAS APLVPGMVAR IGKKNTFLIG
ALLGTCGYLL FFWVSVWSLP VALVALAIAS IGQGVTMTVM WALEADTVEY GEYLTGVRIE
GLTYSLFSFT RKCGQAIGGS IPAFILGLSG YIANQVQTPE VIMGIRTSIA LVPCGFMLLA
FVIIWFYPLT DKKFKEIVVE IDNRKKVQQQ LISDITN
