ID   UIDC_ECOLI              Reviewed;         421 AA.
AC   Q47706; P76178; Q2MB74;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 3.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Membrane-associated protein UidC;
DE   Flags: Precursor;
GN   Name=uidC; Synonyms=gusC; OrderedLocusNames=b1615, JW1607;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Liang W.J., Wilson K.J., Jefferson R.A.;
RT   "The gus genes of Escherichia coli.";
RL   Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   PROTEIN SEQUENCE OF 24-43, CHARACTERIZATION, FUNCTION, INDUCTION, LACK OF
RP   TRANSPORT IN K12, AND SUBCELLULAR LOCATION.
RC   STRAIN=CE1;
RX   PubMed=15774881; DOI=10.1128/jb.187.7.2377-2385.2005;
RA   Liang W.-J., Wilson K.J., Xie H., Knol J., Suzuki S., Rutherford N.G.,
RA   Henderson P.J.F., Jefferson R.A.;
RT   "The gusBC genes of Escherichia coli encode a glucuronide transport
RT   system.";
RL   J. Bacteriol. 187:2377-2385(2005).
CC   -!- FUNCTION: Enhances the activity of the UidB (GusB) glucuronide
CC       transporter, on its own however it has no transport activity.
CC       Glucuronide transport does not occur in strain K12 due to a variant at
CC       position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein.
CC       {ECO:0000269|PubMed:15774881}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000269|PubMed:15774881}.
CC   -!- INDUCTION: In the presence of glucuronides.
CC       {ECO:0000269|PubMed:15774881}.
CC   -!- SIMILARITY: Belongs to the outer membrane porin (Opr) (TC 1.B.25)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA68925.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; M14641; AAA68925.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC74687.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76482.1; -; Genomic_DNA.
DR   PIR; A64918; A64918.
DR   RefSeq; NP_416132.2; NC_000913.3.
DR   RefSeq; WP_001227023.1; NZ_LN832404.1.
DR   AlphaFoldDB; Q47706; -.
DR   SMR; Q47706; -.
DR   BioGRID; 4261073; 179.
DR   DIP; DIP-11088N; -.
DR   IntAct; Q47706; 6.
DR   STRING; 511145.b1615; -.
DR   TCDB; 1.B.25.1.5; the outer membrane porin (opr) family.
DR   PaxDb; Q47706; -.
DR   PRIDE; Q47706; -.
DR   EnsemblBacteria; AAC74687; AAC74687; b1615.
DR   EnsemblBacteria; BAE76482; BAE76482; BAE76482.
DR   GeneID; 944820; -.
DR   KEGG; ecj:JW1607; -.
DR   KEGG; eco:b1615; -.
DR   PATRIC; fig|1411691.4.peg.646; -.
DR   EchoBASE; EB2534; -.
DR   eggNOG; ENOG502ZARH; Bacteria.
DR   HOGENOM; CLU_055413_0_0_6; -.
DR   OMA; GAMGQFA; -.
DR   BioCyc; EcoCyc:G6866-MON; -.
DR   PRO; PR:Q47706; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IDA:EcoCyc.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR005318; OM_porin_bac.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   Pfam; PF03573; OprD; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Membrane;
KW   Porin; Reference proteome; Signal; Sugar transport; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:15774881"
FT   CHAIN           24..421
FT                   /note="Membrane-associated protein UidC"
FT                   /id="PRO_0000022625"
FT   CONFLICT        106..109
FT                   /note="GFAL -> ALP (in Ref. 1; AAA68925)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  46648 MW;  E900FEBF9FE1C7EE CRC64;
     MRKIVAMAVI CLTAASGLTS AYAAQLADDE AGLRIRLKNE LRRADKPSAG AGRDIYAWVQ
     GGLLDFNSGY YSNIIGVEGG AYYVYKLGAR ADMSTRWYLD GDKSFGFALG AVKIKPSENS
     LLKLGRFGTD YSYGSLPYRI PLMAGSSQRT LPTVSEGALG YWALTPNIDL WGMWRSRVFL
     WTDSTTGIRD EGVYNSQTGK YDKHRARSFL AASWHDDTSR YSLGASVQKD VSNQIQSILE
     KSIPLDPNYT LKGELLGFYA QLEGLSRNTS QPNETALVSG QLTWNAPWGS VFGSGGYLRH
     AMNGAVVDTD IGYPFSLSLD RNREGMQSWQ LGVNYRLTPQ FTLTFAPIVT RGYESSKRDV
     RIEGTGILGG MNYRVSEGPL QGMNFFLAAD KGREKRDGST LGDRLNYWDV KMSIQYDFML
     K