UIDR_ECOLI
ID UIDR_ECOLI Reviewed; 196 AA.
AC P0ACT6; P76892; P76895; Q59431;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=HTH-type transcriptional regulator UidR;
DE AltName: Full=Gus operon repressor;
DE AltName: Full=Uid operon repressor;
GN Name=uidR; Synonyms=gusR; OrderedLocusNames=b1618, JW1610;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RA Wilson K.J., Jefferson R.A.;
RT "The GusR repressor of Esherichia coli.";
RL Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Repressor for the uidRABC (gusRABC) operon.
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DR EMBL; M14641; AAA68922.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74690.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15369.1; -; Genomic_DNA.
DR PIR; D64918; D64918.
DR RefSeq; NP_416135.1; NC_000913.3.
DR RefSeq; WP_000969092.1; NZ_STEB01000003.1.
DR AlphaFoldDB; P0ACT6; -.
DR SMR; P0ACT6; -.
DR BioGRID; 4263484; 19.
DR BioGRID; 850510; 3.
DR DIP; DIP-48053N; -.
DR IntAct; P0ACT6; 11.
DR STRING; 511145.b1618; -.
DR jPOST; P0ACT6; -.
DR PaxDb; P0ACT6; -.
DR PRIDE; P0ACT6; -.
DR EnsemblBacteria; AAC74690; AAC74690; b1618.
DR EnsemblBacteria; BAA15369; BAA15369; BAA15369.
DR GeneID; 58389290; -.
DR GeneID; 946150; -.
DR KEGG; ecj:JW1610; -.
DR KEGG; eco:b1618; -.
DR PATRIC; fig|511145.12.peg.1689; -.
DR EchoBASE; EB2533; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_15_12_6; -.
DR InParanoid; P0ACT6; -.
DR OMA; AINHYFS; -.
DR PhylomeDB; P0ACT6; -.
DR BioCyc; EcoCyc:G6867-MON; -.
DR PRO; PR:P0ACT6; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEP:EcoCyc.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..196
FT /note="HTH-type transcriptional regulator UidR"
FT /id="PRO_0000070628"
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 196 AA; 21799 MW; 22912EF7695268D4 CRC64;
MMDNMQTEAQ PTRTRILNAA REIFSENGFH SASMKAICKS CAISPGTLYH HFISKEALIQ
AIILQDQERA LARFREPIEG IHFVDYMVES IVSLTHEAFG QRALVVEIMA EGMRNPQVAA
MLKNKHMTIT EFVAQRMRDA QQKGEISPDI NTAMTSRLLL DLTYGVLADI EAEDLAREAS
FAQGLRAMIG GILTAS
