ID   UIDR_SHIFL              Reviewed;         196 AA.
AC   P0ACT9; P76892; P76895; Q59431;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=HTH-type transcriptional regulator UidR;
DE   AltName: Full=Uid operon repressor;
GN   Name=uidR; OrderedLocusNames=SF1641, S1772;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Repressor for the uidRABC (gusRABC) operon. {ECO:0000250}.
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DR   EMBL; AE005674; AAN43223.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17110.1; -; Genomic_DNA.
DR   RefSeq; NP_707516.1; NC_004337.2.
DR   RefSeq; WP_000969092.1; NZ_WPGW01000024.1.
DR   AlphaFoldDB; P0ACT9; -.
DR   SMR; P0ACT9; -.
DR   STRING; 198214.SF1641; -.
DR   EnsemblBacteria; AAN43223; AAN43223; SF1641.
DR   EnsemblBacteria; AAP17110; AAP17110; S1772.
DR   GeneID; 1024844; -.
DR   GeneID; 58389290; -.
DR   KEGG; sfl:SF1641; -.
DR   KEGG; sfx:S1772; -.
DR   PATRIC; fig|198214.7.peg.1936; -.
DR   HOGENOM; CLU_069356_15_12_6; -.
DR   OMA; AINHYFS; -.
DR   OrthoDB; 2047542at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..196
FT                   /note="HTH-type transcriptional regulator UidR"
FT                   /id="PRO_0000070631"
FT   DOMAIN          10..70
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   196 AA;  21799 MW;  22912EF7695268D4 CRC64;
     MMDNMQTEAQ PTRTRILNAA REIFSENGFH SASMKAICKS CAISPGTLYH HFISKEALIQ
     AIILQDQERA LARFREPIEG IHFVDYMVES IVSLTHEAFG QRALVVEIMA EGMRNPQVAA
     MLKNKHMTIT EFVAQRMRDA QQKGEISPDI NTAMTSRLLL DLTYGVLADI EAEDLAREAS
     FAQGLRAMIG GILTAS