ID   UIF_BOVIN               Reviewed;         318 AA.
AC   Q17QU6; Q95M42;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=UAP56-interacting factor;
DE   AltName: Full=Forty-two-three domain-containing protein 1;
DE            Short=Protein 40-2-3;
GN   Name=FYTTD1; Synonyms=UIF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schmidt T.;
RL   Thesis (2001), Faculty of Biological Sciences / Goettingen, Germany.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for mRNA export from the nucleus to the cytoplasm.
CC       Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure
CC       efficient mRNA export and delivering to the nuclear pore. Associates
CC       with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DDX39B/UAP56 and NXF1; interaction with
CC       DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1;
CC       required for its recruitment to mRNAs. Interacts with CHTOP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus
CC       speckle {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UIF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC51428.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ344095; CAC51428.1; ALT_FRAME; mRNA.
DR   EMBL; BC118174; AAI18175.1; -; mRNA.
DR   RefSeq; NP_001001137.1; NM_001001137.1.
DR   AlphaFoldDB; Q17QU6; -.
DR   SMR; Q17QU6; -.
DR   STRING; 9913.ENSBTAP00000043895; -.
DR   PaxDb; Q17QU6; -.
DR   PRIDE; Q17QU6; -.
DR   Ensembl; ENSBTAT00000046614; ENSBTAP00000043895; ENSBTAG00000014874.
DR   GeneID; 407149; -.
DR   KEGG; bta:407149; -.
DR   CTD; 84248; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014874; -.
DR   VGNC; VGNC:29164; FYTTD1.
DR   eggNOG; ENOG502QWD4; Eukaryota.
DR   GeneTree; ENSGT00390000012807; -.
DR   HOGENOM; CLU_076911_0_0_1; -.
DR   InParanoid; Q17QU6; -.
DR   OMA; QNRAQQF; -.
DR   OrthoDB; 1377721at2759; -.
DR   TreeFam; TF336232; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000014874; Expressed in spermatocyte and 108 other tissues.
DR   ExpressionAtlas; Q17QU6; baseline.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR   InterPro; IPR009782; FYTTD1.
DR   PANTHER; PTHR21038; PTHR21038; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; mRNA transport; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding; Transport; Ubl conjugation.
FT   CHAIN           1..318
FT                   /note="UAP56-interacting factor"
FT                   /id="PRO_0000287440"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           27..45
FT                   /note="UAP56-binding motif"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT   MOD_RES         14
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91Z49"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT   MOD_RES         61
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT   MOD_RES         118
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT   CROSSLNK        140
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO1)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT   CROSSLNK        261
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT   CONFLICT        195
FT                   /note="R -> G (in Ref. 1; CAC51428)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   318 AA;  35976 MW;  3CDD7602267CDB8C CRC64;
     MNRFSTRLMG ATATPPPAPP KARSNENLDK IDMSLDDIIK LNRKEGKKQN FPRLNRRLQQ
     SSARQFRMRV RWGIQQNSGF GKNSLSRRGR VMPGKRRPYG VITGLAARKA TGIRKGISPM
     NRPPLSDKNI ERYFPALKRK ANLLRQNEVQ RKPVAALKRP NQLNRKNNIP NNFTRSGNKL
     SHQKDTRQAT FLFRRGLKVQ AQLNSEQLLD DVVAKRTRQW RTSTTNGGIL TVSIDNPGAV
     QCPVTQKPRL TRTAVPSFLT KRDQSDIKKV PKGVPLQFDI NSVGKQTGMT LNERFGILKE
     QRATLTFNKG GSRFVTVG