ID   UIF_CHICK               Reviewed;         307 AA.
AC   Q5ZJ20;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=UAP56-interacting factor;
DE   AltName: Full=Forty-two-three domain-containing protein 1;
DE            Short=Protein 40-2-3;
GN   Name=FYTTD1; Synonyms=UIF; ORFNames=RCJMB04_21k3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=19836239; DOI=10.1016/j.cub.2009.09.041;
RA   Hautbergue G.M., Hung M.L., Walsh M.J., Snijders A.P., Chang C.T.,
RA   Jones R., Ponting C.P., Dickman M.J., Wilson S.A.;
RT   "UIF, a new mRNA export adaptor that works together with REF/ALY, requires
RT   FACT for recruitment to mRNA.";
RL   Curr. Biol. 19:1918-1924(2009).
CC   -!- FUNCTION: Required for mRNA export from the nucleus to the cytoplasm.
CC       Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure
CC       efficient mRNA export and delivering to the nuclear pore (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus
CC       speckle {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:19836239}.
CC   -!- SIMILARITY: Belongs to the UIF family. {ECO:0000305}.
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DR   EMBL; AJ720614; CAG32273.1; -; mRNA.
DR   RefSeq; NP_001026487.1; NM_001031316.1.
DR   AlphaFoldDB; Q5ZJ20; -.
DR   STRING; 9031.ENSGALP00000012245; -.
DR   PaxDb; Q5ZJ20; -.
DR   PRIDE; Q5ZJ20; -.
DR   Ensembl; ENSGALT00000089010; ENSGALP00000059362; ENSGALG00000007581.
DR   GeneID; 424921; -.
DR   KEGG; gga:424921; -.
DR   CTD; 84248; -.
DR   VEuPathDB; HostDB:geneid_424921; -.
DR   eggNOG; ENOG502QWD4; Eukaryota.
DR   GeneTree; ENSGT00390000012807; -.
DR   HOGENOM; CLU_076911_0_0_1; -.
DR   InParanoid; Q5ZJ20; -.
DR   OMA; QNRAQQF; -.
DR   PhylomeDB; Q5ZJ20; -.
DR   TreeFam; TF336232; -.
DR   Reactome; R-GGA-72187; mRNA 3'-end processing.
DR   Reactome; R-GGA-73856; RNA Polymerase II Transcription Termination.
DR   PRO; PR:Q5ZJ20; -.
DR   Proteomes; UP000000539; Chromosome 9.
DR   Bgee; ENSGALG00000007581; Expressed in spermatid and 14 other tissues.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR   InterPro; IPR009782; FYTTD1.
DR   PANTHER; PTHR21038; PTHR21038; 1.
PE   2: Evidence at transcript level;
KW   mRNA transport; Nucleus; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..307
FT                   /note="UAP56-interacting factor"
FT                   /id="PRO_0000287443"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          41..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           26..44
FT                   /note="UAP56-binding motif"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34332 MW;  644DC9C6FEEAC574 CRC64;
     MSGFGAAALL SGSSAAAGTR SGSSDSLEKI DMSLDDIIKL NKKEERKQYS PKMKRGLQQN
     RTQQFRTPGS KWGIQQQKGY GKNHLGHRKK IVGKKRPYGV ITGLAAKKAM GSHKGISPLN
     RQPLSEKNTQ RNYPILKKKP NLQRQTEMQR KQIPALRRPA PLSRRIGNKL NQQKDTRQAT
     FLFRRGLKVQ AQVQPTEDLD NQAAKRTRQW RTSTTSGGIL TVSIENPGAI ITPISQKLRL
     TRTPVPPFLM KKDQSEEKKI PKGVPLQFDI NSVGKQTGMT LNERFGILKE QRTALSQNKG
     SRFVTVG