UIF_MOUSE
ID UIF_MOUSE Reviewed; 317 AA.
AC Q91Z49; Q3TJ68; Q3UT89; Q8BVM8; Q8K361; Q921B0; Q9D6A8;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=UAP56-interacting factor;
DE AltName: Full=Forty-two-three domain-containing protein 1;
DE Short=Protein 40-2-3;
GN Name=Fyttd1; Synonyms=Uif;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Egg, Liver, Lung, Pancreas, Placenta, Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-317 (ISOFORM 1).
RA Schmidt T.;
RL Thesis (2001), Faculty of Biological Sciences / Goettingen, Germany.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14 AND SER-23, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP INTERACTION WITH CHTOP.
RX PubMed=22872859; DOI=10.1074/mcp.m112.017194;
RA Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J.,
RA Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.;
RT "Five friends of methylated chromatin target of protein-arginine-
RT methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation
RT to desumoylation.";
RL Mol. Cell. Proteomics 11:1263-1273(2012).
CC -!- FUNCTION: Required for mRNA export from the nucleus to the cytoplasm.
CC Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure
CC efficient mRNA export and delivering to the nuclear pore. Associates
CC with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DDX39B/UAP56 and NXF1; interaction with
CC DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1;
CC required for its recruitment to mRNAs (By similarity). Interacts with
CC CHTOP. {ECO:0000250, ECO:0000269|PubMed:22872859}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus
CC speckle {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q91Z49-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91Z49-2; Sequence=VSP_025463, VSP_025464;
CC Name=3;
CC IsoId=Q91Z49-3; Sequence=VSP_025462;
CC -!- SIMILARITY: Belongs to the UIF family. {ECO:0000305}.
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DR EMBL; AK014447; BAB29357.1; -; mRNA.
DR EMBL; AK029785; BAC26615.1; -; mRNA.
DR EMBL; AK050448; BAC34260.1; -; mRNA.
DR EMBL; AK050479; BAC34279.1; -; mRNA.
DR EMBL; AK077184; BAC36666.1; -; mRNA.
DR EMBL; AK139638; BAE24091.1; -; mRNA.
DR EMBL; AK157602; BAE34132.1; -; mRNA.
DR EMBL; AK161252; BAE36271.1; -; mRNA.
DR EMBL; AK166032; BAE38533.1; -; mRNA.
DR EMBL; AK167564; BAE39627.1; -; mRNA.
DR EMBL; AK170511; BAE41848.1; -; mRNA.
DR EMBL; BC010204; AAH10204.1; -; mRNA.
DR EMBL; BC028253; AAH28253.1; -; mRNA.
DR EMBL; AJ344096; CAC51437.1; -; mRNA.
DR CCDS; CCDS28125.1; -. [Q91Z49-1]
DR CCDS; CCDS49833.1; -. [Q91Z49-2]
DR RefSeq; NP_001152821.1; NM_001159349.1. [Q91Z49-2]
DR RefSeq; NP_081502.2; NM_027226.4. [Q91Z49-1]
DR AlphaFoldDB; Q91Z49; -.
DR BioGRID; 213703; 3.
DR IntAct; Q91Z49; 1.
DR STRING; 10090.ENSMUSP00000023489; -.
DR iPTMnet; Q91Z49; -.
DR PhosphoSitePlus; Q91Z49; -.
DR SwissPalm; Q91Z49; -.
DR EPD; Q91Z49; -.
DR jPOST; Q91Z49; -.
DR MaxQB; Q91Z49; -.
DR PaxDb; Q91Z49; -.
DR PeptideAtlas; Q91Z49; -.
DR PRIDE; Q91Z49; -.
DR ProteomicsDB; 298430; -. [Q91Z49-1]
DR ProteomicsDB; 298431; -. [Q91Z49-2]
DR ProteomicsDB; 298432; -. [Q91Z49-3]
DR Antibodypedia; 54015; 142 antibodies from 19 providers.
DR DNASU; 69823; -.
DR Ensembl; ENSMUST00000023489; ENSMUSP00000023489; ENSMUSG00000022800. [Q91Z49-1]
DR Ensembl; ENSMUST00000171325; ENSMUSP00000131446; ENSMUSG00000022800. [Q91Z49-2]
DR Ensembl; ENSMUST00000232272; ENSMUSP00000155929; ENSMUSG00000022800. [Q91Z49-3]
DR GeneID; 69823; -.
DR KEGG; mmu:69823; -.
DR UCSC; uc007yzp.2; mouse. [Q91Z49-1]
DR UCSC; uc007yzq.2; mouse. [Q91Z49-2]
DR CTD; 84248; -.
DR MGI; MGI:1917955; Fyttd1.
DR VEuPathDB; HostDB:ENSMUSG00000022800; -.
DR eggNOG; ENOG502QWD4; Eukaryota.
DR GeneTree; ENSGT00390000012807; -.
DR HOGENOM; CLU_076911_0_0_1; -.
DR InParanoid; Q91Z49; -.
DR OMA; QNRAQQF; -.
DR OrthoDB; 1377721at2759; -.
DR PhylomeDB; Q91Z49; -.
DR TreeFam; TF336232; -.
DR Reactome; R-MMU-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-MMU-72187; mRNA 3'-end processing.
DR Reactome; R-MMU-73856; RNA Polymerase II Transcription Termination.
DR BioGRID-ORCS; 69823; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Fyttd1; mouse.
DR PRO; PR:Q91Z49; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q91Z49; protein.
DR Bgee; ENSMUSG00000022800; Expressed in spermatocyte and 269 other tissues.
DR ExpressionAtlas; Q91Z49; baseline and differential.
DR Genevisible; Q91Z49; MM.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR InterPro; IPR009782; FYTTD1.
DR PANTHER; PTHR21038; PTHR21038; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Isopeptide bond; mRNA transport;
KW Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transport;
KW Ubl conjugation.
FT CHAIN 1..317
FT /note="UAP56-interacting factor"
FT /id="PRO_0000287442"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 26..44
FT /note="UAP56-binding motif"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT CROSSLNK 139
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT CROSSLNK 260
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT VAR_SEQ 1..118
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_025462"
FT VAR_SEQ 166..174
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025463"
FT VAR_SEQ 219..243
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025464"
FT CONFLICT 73
FT /note="I -> V (in Ref. 3; CAC51437)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="L -> V (in Ref. 2; AAH28253)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="S -> C (in Ref. 3; CAC51437)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="V -> G (in Ref. 1; BAB29357)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 35887 MW; 03182120505F4F83 CRC64;
MNRFGTRLVG ATATPPPPPK ARSNENLDKI DMSLDDIIKL NRKEGKKQNF PRLNRRLQQS
GTRQFRMRVR WGIQQNSGFG KTSLSRRGRV LPGKRRPYGV ITGLAARKAT GIRKGISPMN
RPPLSDKNIE RYFPALKRKT SLLRQNEVQR KQVAVLKRPN QLNRKNNIPA NFTRNGNKLS
HQKDTRQATF LFRRGLKVQT QLNTEQLIDD VVAKRTRQWR TSTTNGGILT VSIDNPGAVQ
CPVTQKPRLT RTAVPSFLTK REQSDVKKVP KGVPLQFDIN SVGKQTGMTL NERFGILKEQ
RANLTFSKGG SRFVTVG
