UIF_RAT
ID UIF_RAT Reviewed; 317 AA.
AC Q7TQ84;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 2.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=UAP56-interacting factor;
DE AltName: Full=Forty-two-three domain-containing protein 1;
DE Short=Protein 40-2-3;
GN Name=Fyttd1; Synonyms=Uif; ORFNames=Ac1176;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Sprague-Dawley;
RA Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for mRNA export from the nucleus to the cytoplasm.
CC Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure
CC efficient mRNA export and delivering to the nuclear pore. Associates
CC with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DDX39B/UAP56 and NXF1; interaction with
CC DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1;
CC required for its recruitment to mRNAs. Interacts with CHTOP (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus
CC speckle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UIF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP78754.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AABR03078527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY310146; AAP78754.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001041364.1; NM_001047899.2.
DR AlphaFoldDB; Q7TQ84; -.
DR STRING; 10116.ENSRNOP00000044272; -.
DR PaxDb; Q7TQ84; -.
DR PRIDE; Q7TQ84; -.
DR GeneID; 360726; -.
DR KEGG; rno:360726; -.
DR UCSC; RGD:1306899; rat.
DR CTD; 84248; -.
DR RGD; 1306899; Fyttd1.
DR eggNOG; ENOG502QWD4; Eukaryota.
DR InParanoid; Q7TQ84; -.
DR OrthoDB; 1377721at2759; -.
DR PhylomeDB; Q7TQ84; -.
DR Reactome; R-RNO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-RNO-72187; mRNA 3'-end processing.
DR Reactome; R-RNO-73856; RNA Polymerase II Transcription Termination.
DR PRO; PR:Q7TQ84; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR InterPro; IPR009782; FYTTD1.
DR PANTHER; PTHR21038; PTHR21038; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isopeptide bond; mRNA transport; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding; Transport; Ubl conjugation.
FT CHAIN 1..317
FT /note="UAP56-interacting factor"
FT /id="PRO_0000390995"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 26..44
FT /note="UAP56-binding motif"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q91Z49"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT CROSSLNK 139
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
FT CROSSLNK 260
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96QD9"
SQ SEQUENCE 317 AA; 35642 MW; 9396444E7F785C28 CRC64;
MNRFGTRLVG ATATTPPAPK ARSNENLDKI DMSLDEIIKL NRKEGKKQSF PRLNRRLQQS
GARQLRMRVR WGVQQSSGFG KTSVSRRGRV LPGKRRPYGV ITGLAARKAT GIRKGISPMN
RPPLSDKNIE RYFPALKRKT SLLRQNEVQR KPVAVLKRPN QLNRKNNIPA NFTRSGNKLS
HQKDTRQATF LFRRGLKVQT QLNTEQLIDD VVAKRTRQWR TSTTNGGILT VSIDNPGAVQ
CPVTQKPRLT RTAVPSFLTK REQSDVKKIP KGVPLQFDIN SVGKQTGMTL NERFGILKEQ
RAALPFSKGG SRFVTVG
